Microbiological and immunological indicators in patients with acute cholecystitis

The causative agents of acute destructive cholecystitis and wound complications are various pyogenic bacteria including staphylococci, enterococci, Escherichia, Proteus, and anaerobes among which certain varieties, serogroups, and phagocytes predominate. Most bacteria, with the exception of anaerobes, are resistant to penicillin, streptomycin, and chlortetracycline but retain sensitivity to antibiotics of the neomycin series and other chemotherapeutic agents. In most patients with phlegmonous cholecystitis specific antibodies accumulated in the blood during the disease irrespective of one another, while the intensity of their increase was determined by the duration of treatment and the patients' age. The dynamics of changes of the specific antibody titres may confirm the etiology of cholecystitis and be an indirect sign of the prognosis of the disease.