符合中药特点的致癌风险评价方法

如何对中药的致癌性风险作出科学而合理的评价是毒理学研究的难点之一。因中药成分和配伍的复杂性，现有的常规遗传毒性评价方法在评价中药方面有所局限。在原有试验原理基础上开发高通量筛选方法，以及利用新型生物标志物和基于新原理的试验技术已在中药毒性预测和评价领域显露一定的应用价值。本文聚焦适合大量成分毒性筛选及靶器官毒性评价的试验方法，包括改良的传统试验方法、自动化检测手段、生物标志物、三维组织培养技术和计算机毒理学的引入等，为中药致癌性评价提供借鉴思路。

Cancer Risk Assessment Methods in Accordance with the Characteristics of Traditional Chinese Medicine

To make a scientific and reasonable assessment for the carcinogenic risk of traditional Chinese medicine (TCM) is one of the chanllenges in toxicology evaluation. However, conventional genotoxicity evaluation methods are limited in the evaluation of TCMs due to the complexity and the compatibility of their components. The development of high throughput screening method based on the original principles and the use of new biomarkers and techniques based on novel principles have shown certain application value in the fields of toxicity prediction and evaluation of TCMs. This article focuses on the test methods that are feasible for the toxicity screening of a large number of components and the target organ toxicity evaluation, including improved traditional test methods, automated detection methods, the introduction of biomarkers, three-dimensional tissue culture techniques and computer toxicology, etc., which shall provide references for the carcinogenicity evaluation of TCMs.