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| 水溶性药物脂质体制备方法的研究进展 | |
| 引用本文： | 王荷逸,黄思凡,王邦国,武鑫,陈建明.水溶性药物脂质体制备方法的研究进展[J].中国药学杂志,2021,55(23):1935-1938. |
| 作者姓名： | 王荷逸 黄思凡 王邦国 武鑫 陈建明 |
| 作者单位： | 1.内蒙古医科大学药学院, 呼和浩特 010110; 2.福建中医药大学药学院, 福州 350122; 3.上海维洱实验室, 上海 201712 |
| 基金项目： | 国家自然科学基金项目资助(81772749);上海市青年科技启明星计划资助(18QB1400400);上海市科技小巨人工程项目资助(1902HX76600);上海青浦区产学研合作发展资金项目资助(青产学研2019-5) |
| 摘 要： | 根据目前水溶性药物易泄漏、包封率低的不足,查阅近几年国内外相关文献,对其制备方法进行综述。总结水溶性药物脂质体制备方法的研究进展,为水溶性药物脂质体制备提供参考。脂质体包载水溶性药物在实验室研究中已取得不错的成果,但大工业生产较困难,还需深入研究。 |
| 关 键 词： | 水溶性药物 脂质体 制备方法 |
| 收稿时间： | 2020-04-29 |
Progress on Preparation Method of Water-Soluble Drug Liposomes |
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| WANG He-yi,HUANG Si-fan,WANG Bang-guo,WU Xin,CHEN Jian-ming.Progress on Preparation Method of Water-Soluble Drug Liposomes[J].Chinese Pharmaceutical Journal,2021,55(23):1935-1938. | |
| Authors: | WANG He-yi HUANG Si-fan WANG Bang-guo WU Xin CHEN Jian-ming |
| Institution: | 1. School of Pharmacy, Inner Mongolia Medical University, Hohhot 010110, China; 2. School of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China; 3. Shanghai Weier Laboratory, Shanghai 201712, China |
| Abstract: | To summarize the research progress of the preparation methods of water-soluble drug liposomes and provide reference for the preparation of water-soluble drug liposomes. According to the current shortcomings of easy leakage of water-soluble drugs and low encapsulation rate, the preparation methods of water-soluble drugs were reviewed by referring to relevant literatures in recent years. Liposome-encapsulated water-soluble drug has achieved good results in laboratory research, but it is difficult to produce in large industry, and further research is needed. |
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