| 共无定形盐酸鲁拉西酮-莽草酸的稳定性研究 |
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| 引用本文： | 卢山, 邢天嫣, 胡义, 薛大权, 李彬, 肖学成. 共无定形盐酸鲁拉西酮-莽草酸的稳定性研究[J]. 中国现代应用药学, 2021, 38(20): 2505-2511. DOI: 10.13748/j.cnki.issn1007-7693.2021.20.005 |
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| 作者姓名： | 卢山 邢天嫣 胡义 薛大权 李彬 肖学成 |
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| 作者单位： | 1.湖北中医药大学药学院, 武汉 430065 |
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| 摘 要： | 目的 建立盐酸鲁拉西酮的含量测定方法,并对盐酸鲁拉西酮-莽草酸共无定形体系的稳定性进行研究.方法 采用溶剂法(真空减压旋转蒸发法)制备得到3种摩尔比为1∶1,1∶2及2∶1的共无定形盐酸鲁拉西酮-莽草酸,采用熔点仪、偏光显微镜、HPLC、PXRD等方法对共无定形盐酸鲁拉西酮-莽草酸进行了理化性质的考察.结果 制备的3种...
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| 关 键 词： | 盐酸鲁拉西酮 莽草酸 共无定形 稳定性 |
| 收稿时间： | 2021-02-08 |
Investigation on the Stability of Coamorphous Lurasidone Hydrochloride-shikimic Acid |
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| LU Shan, XING Tianyan, HU Yi, XUE Daquan, LI Bin, XIAO Xuecheng. Investigation on the Stability of Coamorphous Lurasidone Hydrochloride-shikimic Acid[J]. Chinese Journal of Modern Applied Pharmacy, 2021, 38(20): 2505-2511. DOI: 10.13748/j.cnki.issn1007-7693.2021.20.005 |
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| Authors: | LU Shan XING Tianyan HU Yi XUE Daquan LI Bin XIAO Xuecheng |
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| Affiliation: | 1.School of Pharmacy, Hubei University of Chinese Medicine, Wuhan 430065, China |
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| Abstract: | OBJECTIVE To establish a method for the determination of lurasidone hydrochloride and to study the stability of the lurasidone hydrochloride-shikimic acid coamorphous system. METHODS Three kinds of coamorphous lurasidone hydrochloride-shikimic acid with molar ratios of 1:1, 1:2 and 2:1 were prepared by the solvent method(vacuum and reduced pressure rotary evaporation method), using melting point instrument and polarizing microscope. The physical and chemical properties of the coamorphous lurasidone hydrochloride-shikimic acid were investigated by methods such as HPLC and PXRD. RESULTS Among the three prepared coamorphous lurasidone-shikimic acid, the coamorphous one with a molar ratio of 1:2 was the most stable. CONCLUSION By increasing the ratio of shikimic acid, the stability of the coamorphous form can be improved. |
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| Keywords: | lurasidone hydrochloride shikimic acid coamorphous stability |
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