| 强啡肽致脊髓损伤中非阿片样受体机制的研究 |
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| 引用本文： | 李明,陈语,侯铁胜,曹莉,陈强,倪春鸿. 强啡肽致脊髓损伤中非阿片样受体机制的研究[J]. 第二军医大学学报, 2001, 22(10): 923-925 |
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| 作者姓名： | 李明 陈语 侯铁胜 曹莉 陈强 倪春鸿 |
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| 作者单位： | 第二军医大学附属长海医院;第二军医大学附属长海医院;第二军医大学附属长海医院;第二军医大学附属长海医院;第二军医大学附属长海医院 |
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| 基金项目： | 上海市科技启明星计划资助项目 ( 98Q14 0 0 6 ) |
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| 摘 要： | 目的：探讨强啡肽（dynorphin,Dyn）致脊髓损伤的作用中是否有兴奋性氨基酸的N－甲基－D－门冬氨酸（NMDA）受体通过非阿片途径进行介导,为临床治疗脊髓继发性损伤提供新的思路。方法：通过大鼠蛛网膜下腔置管注药模型,观察不同剂量的非竞争性NMDA受体拮抗剂MK－801对DynA(1-13）致脊髓损伤作用中神经功能和组织病理改变的影响。结果：预先鞘内注射MK－801能明显缓解DynA(1-13)对神经功能和组织病理的损害作用,且呈一定的量效关系。结论：强啡肽致脊髓损伤的非阿片途径中至少有一定部分是通过NMDA受体介导的。
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| 关 键 词： | 脊髓损伤 强啡肽 受体 N-甲基-D-门冬氨酸 |
| 文章编号： | 0258-879(2001)10-0923-03 |
| 修稿时间： | 2001-05-18 |
Research on mechanism of non-opioid receptor in dynorphin-induced spinal cord injury |
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| LI Ming ,CHEN Yu ,HOU Tie Sheng ,CAO Li ,CHEN Qiang ,NI Chun Hong. Research on mechanism of non-opioid receptor in dynorphin-induced spinal cord injury[J]. Former Academic Journal of Second Military Medical University, 2001, 22(10): 923-925 |
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| Authors: | LI Ming CHEN Yu HOU Tie Sheng CAO Li CHEN Qiang NI Chun Hong |
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| Affiliation: | LI Ming 1,CHEN Yu 1,HOU Tie Sheng 1,CAO Li 2,CHEN Qiang 1,NI Chun Hong 1 |
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| Abstract: | Objective:To study wheather N methyl D asparate receptor (NMDAR) was involved in the receptor mechanism of dynorphin (Dyn) induced spinal cord injuries through a non opioid action. Methods:The effect of MK 801, a non competitive NMDAR antagonist, on the alteration of motor function and neuropathology induced by intrathecal administration of DynA(1 13) were examined. Results:Pretreatment with MK 801 significantly attenuated the neurologic dysfunction and improved the histopathological status associated with DynA(1 13) administration in a dose related manner. Conclusion:It is suggested that the non opioid component of DynA induced spinal cord injuries are mediated, in part, by the NMDA receptor. |
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| Keywords: | spinal cord injuries dynorphin receptors N methyl D asparate |
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