癌因性疲乏对乳腺癌病人化疗期间生活质量的影响

目的调查乳腺癌病人化疗期间的癌因性疲乏及生活质量状况并分析癌因性疲乏对生活质量的影响。方法应用Piper疲乏修订量表(中文版)及SF-36健康状况量表调查了98例乳腺癌病人门诊化疗期间的癌因性疲乏状况及其生活质量状况。结果本组乳腺癌化疗病人存在疲乏的有63例,占64.29%,其中,中至重度疲乏的有39例,占39.80%。乳腺癌病人化疗期间SF-36生理机能、生理职能、躯体疼痛、一般健康状况、精力、社会功能、情感职能共7个维度得分均低于国内正常人群(P0.01)。经多元逐步回归分析发现,年龄、疲乏状况总分及癌因性疲乏行为及严重性、情绪和认知、情感3个维度对于除精神健康外的生活质量的7维度有影响(P0.01)。结论乳腺癌病人化疗期间的生活质量低于正常人群,癌因性疲乏为其化疗期间的常见症状。年龄、癌因性疲乏是导致本组乳腺癌病人生活质量降低的主要因素。

The effect of cancer-related fatigue on the quality of life in breast cancer patients undergoing chemotherapy

Objectives To explore the status of cancer - related fatigue and quality of life in breast cancer patients receiving chemotherapy and analyze the influence of eancer - related fatigue on quality of life. Methods Ninety - eight breast cancer patients were recruited in this study. Data regarding the cancer - related fatigue and quality of life in breast cancer patients were collected by RPFS - C （ Revised Piper Fatigue Scale - Chinese Version） and SF - 36 （Short Form 36） Itealth Survey Questionnaire. Results The prevalenee of cancer - related fatigue of breast cancer patients receiving chemotherapy was 64.29% ,including 30.61% moderate degree. The 7 subscales（ Physical Functioning, Role - Physical, Bodily Pain, General Health, Vitality, Social Functioning, Role - Emotional） scores of SF - 36 in breast cancer patients receiving chemotherapy were lower than those of domestic normal people （ P 〈 0.01 ）. Liner regression analysis showed that age,the scores of RPFS and behavioral/severity,cognitive/nmod,affective meaning had significant eftects on 7 subscales scores except General Health of SF - 36 （ P 〈 0. 01 ）. Conclusions The quality of life in breast cancer patients receiving chemotherapy is worse than domestic normal people. Age and cancer - related fatigue are the main factors affecting quality of life in breast cancer patients.