2型糖尿病胰岛素抵抗与认知功能障碍关系研究

目的探讨2型糖尿病胰岛素抵抗(insilin-resistance,IR)患者与认知功能的关系;明确IR是否为认知功能障碍的危险因素.方法对106例2型糖尿病患者进行认知功能问卷调查,并选用胰岛素敏感指数(insulin sentivityindex,ISI)评价胰岛素抵抗.结果 IR患者组认知功能障碍发病率高,且重型IR患者高于轻型IR患者、以血糖控制不良者为甚;认知功能障碍患者组表现IR且空腹血胰岛素水平高(P<0.01),Logistic回归分析显示腰围、体重指数(BM)I、空腹胰岛素水平、促甲状腺激素(TSH)、糖化血红蛋白(HBA1C)最终进入方程.结论 IR进一步加重了2型糖尿病患者的认知功能损害,且IR空腹血胰岛素水平高;IR影响认知功能的各个环节;受教育程度与认知功能呈负相关;腰围、BMI、TSH、IR、胰岛素水平、血糖与认知功能障碍呈正相关.

The Correlation between Type 2 Diabetes Insulin Resistance and Cognitive Dysfunction

Objective To explore the relationship between the patients with insulin resistance of type 2 diabetes(IR)and the cognitive function,and to learn whether IR is the independent risk factor for cognitive function.Method The questionnaire survey of cognitive function was taken in 106 patients with insulin resistance of type 2 diabetes,and the insulin resistance was evaluated with insulin sensitivity index(ISI).Results The group of patients with IR got a higher incidence of cognitive dysfunction,especially for the severe IR patients and the patients with poor control of blood sugar.The patients with cognitive dysfunction showed IR and high fasting blood insulin level(P<0.01),and the waist circumference,body mass index(BMI),fasting insulin levels,TSH,glycated hemoglobin(HBA1C)were analysed by Logistic regression in the equation.Conclusions The cognitive dysfunction of patients with type 2 diabetes is worsened by IR,and the level fasting blood insulin of the patients is high.IR influences all aspects of cognitive function.The cognitative function has negative correlation with education degree and positive correlation with waist circumference,BMI,TSH,IR,insulin levels,and blood sugar.