蚓激酶对糖尿病患者血液流变学、血糖及血脂的影响

目的了解蚓激酶对糖尿病患者的血液流变学、血糖和血脂的影响,以及对糖尿病并发症的防治作用。方法对76例2型糖尿病患者在血糖控制到FPG〈8mmol/L,2hPG〈11mmol/L后,随机分为蚓激酶组40例,对照组36例。蚓激酶组用蚓激酶60万单位口服,日3次,共8周。比较两组治疗前后血液流变学、血糖和血脂的差异。结果蚓激酶组的全血黏度、血浆比黏度、血浆纤维蛋白原浓度、血小板聚集率和甘油三酯均明显降低（P〈0.01）,两组空腹及餐后血糖下降无差异（P〉0.05）。结论蚓激酶对糖尿病患者的血脂,血液流变学指标均有不同程度的改善。

The effect of lumbrokinase treatment on hemorheology,glucose and lipids in type 2 diabetes mellitus

Objective To study the effect of lumbrokinase treatment on hemorheology, glucose and lipids of type 2 diabetes mellitus （T2DM）. Methods 76 cases with T2DM whose blood glucose was controlled at FPG〈8mmol/L and 2hPG〈11mmol/L were involved in the study. All patients were divided into two groups： lumbrokinase （600ku rid for eight weeks） group （n=40） and control group （n=36）. The levels of the blood rheology, glucose and lipids were measured. Results The levels of the whole blood viscosity, plasma viscosity, fibrinogen, platelet aggregation rate and triglyceride were decreased in lumbrokinas group as compared with control groups （all P〈0. 01）. There were no differences in FPG and 2hPG between two groups（P〉0. 05）. Conclusions Lumbrokinase can decrease the levels of the blood rheology and triglyceride in T2DM. It may prevent and cure the complication of diabetes mellitus.