绝经期妇女骨密度与细胞因子的变化

目的：观察绝经后不年龄妇女骨密度与白细胞介素1（IL－1）、白介素6（IL－6）、肿瘤坏死因子（TNF－α水平的变化。探讨骨质疏松症（Ostoporosis,OP)的发病及其机理,方法：用双能X线吸收仪测定207例绝经前后不同年妇女骨密度,采用定量夹心酶联免疫测定血清IL－1、IL－6、TNF－α水平。结果：骨量减少28例,占14．95,OP72例,占38．5％,正常行经对照组20例,骨量减少1例,占0．5％,各年龀组与对照组差异显著（P＜0．01）,结论妇女绝经后,雌激素水平明显下降,雌对因子的抑制降低,因而IL－1、IL－6、TNF－α血清水平明显升高,增强了破骨细胞的活性和形成,使骨转换加快,OP发病率升高。

The Changes of Cytokinesand Bone Mineral Density in Post-Menopausal Women

Objective　To study the pathogenesis of osteoporosis.　Methods　By observing bone mineral density (BMD) and the levels of IL*.1,IL*.6,TNF*.α of 207 women including 187 post-menopausal and 20 normal menstrual women. BMD was measured by DEXA in all women, and serum IL*.1, IL*.6 and TNF*.α levels were measured by quantitative sandwiched ELISA.　Results　Among 207 subjects, 28 wre osteopenia subjects, accounting for 14.9%, and 72 osteoporosis subjects, accounting for 38.5%, but osteopenia occurred in one of 20 normal menstrual women. Tiere were significant differences between post-menopausal and normal menstrual women (P<0.01).　Conclusion　In post-menopausal women, the levels of estrogen is low, the restriction on the secretion of cytokines decreases, so the levels of IL*.1, IL*.6 and TNF*.α increase, the activity and formation of osteoclasts are strengthened, bone remodeling is accelerated, and the morbidity of osteoporosis thus increases.