原发性胆汁反流性胃炎与胃食管反流病的关系

目的:探讨原发性胆汁反流性胃炎(primary bile reflux gastritis,PBRG)与胃食管反流病(gastroesophageal reflux disease,GERD)之间的相关性.方法:选取我院确诊为PBRG的患者1060例为观察组,无痛胃镜下未查见有PBRG的体检者1060例为对照组,比较两组GERD的发生率;依据内镜下PBRG的诊断标准,将260例PBRG伴有GERD的患者分为轻度、中度及重度3组,对比各组食管黏膜损伤的程度以及GERD症状积分的分布.结果:PBRG组GERD的发生率高于对照组(24.5%vs9.8%,P<0.05).食管黏膜损伤程度加深的发生率随着PBRG程度的加重而增加.PBRG的程度与GERD症状分级无相关性.结论:PBRG与反流性食管炎(refluxe sophagitis,RE)形成存在正性相关,PBRG并非是引起GERD症状的主要原因.

Relationship between primary bile reflux gastritis and gastroesophageal reflux disease

AIM: To investigate the relationship between primary bile reflux gastritis (PBRG) and gastroesophageal reflux disease (GERD). METHODS: A total of 1 060 patients diagnosed with PBRG comprised the observation group, and 1 060 people without PBRG were used as controls. The incidence rate of GERD in the two groups was compared. The patients with PBRG and GERD were divided into mild group, moderate group, severe group based on the severity of PBRG. The degree of esophageal mucosal injury and the distribution of GERD symptoms were then compared. RESULTS: The incidence rate of GERD in the PBRG group was higher than that in the control group (24.5% vs 9.8%, P < 0.05). The incidence rate of esophageal mucosal injury increased with the aggravation of PBRG. The degree of PBRG showed no significant association with the distribution of GERD symptoms. CONCLUSION: PBRG has a positive correlation with the formation of reflux esophagitis (RE), and PBRG does not play a major role in producing typical GERD symptoms.