慢性阻塞性肺疾病患者血清IL-6和黏着斑激酶水平检测临床意义

目的 探讨慢性阻塞性肺疾病(COPD)患者检测血清IL-6和粘着斑激酶(FAK)水平的意义。方法 选取COPD患者120例,对照组100例健康人群,通过酶联免疫吸附法(ELISA)检测血清IL-6和FAK水平。结果对照组和COPD各分级组间血尿酸、胆固醇和三酰甘油差异均无统计学意义(F=0.891～1.254,均P>0.05),而FAK和IL-6水平比较差异有统计学意义(F=10.451～25.387,均P<0.05)。COPDⅠ～Ⅳ级IL-6水平有升高的趋势,但各分级组间IL-6水平差异无统计学意义(t=0.098～0.145,均P>0.05)。COPDⅠ～Ⅳ级FAK水平差异有统计学意义(t=33.541～55.612,均P<0.05)。IL-6和FAK存在显著的正相关(r=0.881)。结论 检测血清FAK可反映COPD患者严重程度,且它是呼吸道平滑肌细胞增殖的靶标。

Significance of the Detecting IL-6 and FAKin Chronic Obstructive Pulmonary Disease

Objective To discuss on the significance of detection IL-6 and FAK in chronic obstructive pulmonary disease(COPD).Methods Chosed 120 patients with suspected COPD and 100 cases as control group and detected IL-6 and FAK level by ELISA method.ResultsThere were no statistical difference among UA,TC and TG level between COPD and control group(F=0.891～1.254,P>0.05).However IL-6 and FAK level had statistical difference between COPD and control group(F=10.451～25.387,P<0.05).There was a increased tendency of IL-6 level fromⅠ phaseto Ⅳ phase,but no statistical difference(t=0.098～0.145,P>0.05).There was statistical difference of FAK level fromⅠphase to Ⅳ phase(t=33.541～55.612,P<0.05).IL-6 level was positively related to FAK level(r=-0.881).Conclusion FAK level in serum was detected in orderto diagnose the serious degree of COPD.It can be a new indicator for smooth muscle cell proliferation of respiratory tract.