丙酸氟替卡松鼻喷雾剂对儿童哮喘控制及过敏性鼻炎症状改善的作用

目的 比探讨丙酸氟替卡松鼻喷雾剂在改善儿童过敏性鼻炎症状以及控制哮喘反复发作方面的作用.方法 将100例过敏性鼻炎合并哮喘综合征患儿按照随机数字表法分为对照组和观察组.对照组应用氯雷他定及经口腔吸人糖皮质激素,观察组在此基础上使用丙酸氟替卡松鼻喷雾剂治疗,观察两组疗效.结果 观察组总有效率（94％）明显优于对照组（76％）（x2=6.35,P＜0.05）.10 ～ 12周以后,观察组与对照组鼻炎症状评分及哮喘症状评分差异均有统计学意义（t=2.47、2.64、3.41；2.30、3.17、2.47,均P＜0.05）.不良反应方面两组鼻腔干燥、鼻出血发生率差异均有统计学意义（x2 =7.11、7.53,均P＜0.05）.结论 丙酸氟替卡松鼻喷雾剂在改善儿童过敏性鼻炎和哮喘症状复发方面有很好疗效,值得临床大力推广.

Effect of fluticasone propionate nasal spray in the control of children with asthma and allergic rhinitis

Objective To explore the effect of fluticasone propionate nasal spray（Fu Shu-liang） in improving children＆#39;s symptoms of allergic rhinitis and recurrent asthma.Methods 100 children with allergic rhinitis and asthma syndrome were randomly divided into control group and experimental group.The control group was treated with loratadine.The experimental group was treated with water-soluble auxiliary Fu Shu-liang nasal spay on the basis of the control group.The treatment effects were observed.Results The total effective rate of the observation group was 94%,which was significantly higher than 76% of the control group （x2 =6.35,P 〈 0.05）.After 10-12 weeks,the rhinitis symptom score and asthma symptom score between the two groups had statistically significant differences （t =2.47,2.64,3.41 ; 2.30,3.17,2.47,all P 〈 0.05）.The incidence rate of adverse reactions such as nasal dryness,epistaxis between the two groups had statistically significant differences （x2 =7.11,7.53,all P 〈 0.05）.Conclusion Fu Shu-liang（Eph propionate and fluticasone propionate nasal spray） has good effect in improving symptoms of children with allergic rhinitis and asthma,it is worthy of clinical vigorously promoted.