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| 白芍总苷对急性心肌缺血的保护作用 | |
| 引用本文： | TGP(20 mg.kg-1) Pit. 白芍总苷对急性心肌缺血的保护作用[J]. 中国药理学通报, 1999, 15(3): 30 |
| 作者姓名： | TGP(20 mg.kg-1) Pit |
| 作者单位： | ：蚌埠医学院药理学教研室（祝晓光 韦颖梅）生理学教研室（刘桂兰 韩永勤） |
| 摘 要： | 目的研究白芍总苷对缺血心肌的保护作用。方法采用常压耐缺氧小鼠存活时间，夹闭小鼠气管法和垂体后叶素引起家兔心肌缺血用计算机检测心功能变化等方法。结果白芍总苷能明显延长常压缺氧小鼠存活时间，明显改善垂体后叶素引起家兔缺血心肌的心功能，延长夹闭小鼠气管致心电消失的时间，且剂量依赖性。结论白芍总苷能有效对抗心肌缺血。 |
| 关 键 词： | 白芍总苷；心肌缺血；耐缺氧；左心室功能 |
| 修稿时间： | 1998-12-30 |
Protective effects of total glucosides of pacony root on acute myocardial ischemia in rats and rabbits |
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| Abstract: | AIM To study the protective effects of total glucosides of pacony root(TGP) on acute myocardial ischemia. METHODS The mean survival time of hypoxia under normal pressure, the disappearance time of electrocardiographic sign after clamping the trachea in mice and the experimental myocardial ischemia was induced by injection of pituitrin(2 5 U·kg -1 ) iv in rabbits. The left ventricular function was measured by the computer. RESULTS TGP markedly prolonged the survial time in hypoxia and varied left ventricular function in dose dependent manner. CONCLUSION TGP can antagonise the myocardial ischemia effectively. |
| Keywords: | total glucosides of pacony root(TGP) myocardial ischemia left ventricular function |