代谢综合征在继发性慢性肾脏损害中作用的临床研究

目的：探讨代谢综合征对包括轻度肾功能减退在内的继发性慢性肾脏损害发生、发展的影响。方法：回顾性分析966例合并代谢异常患者的临床资料。结果：（1）有慢性肾损害的患者年龄、BMI、TC、TG、尿酸水平均高于无慢性肾损害患者,而HDL水平明显低于慢性肾损害患者。（2）糖尿病、高血压、冠心病、脑卒中患者慢性肾损害的患病率明显增高。（3）存在2、3、4个代谢综合征成分的病例其慢性肾损害的患病率明显增加,且有随着代谢综合征成分的增多而上升的趋势。（4）糖尿病、高血压、BMI≥25、脂质异常等相互并存,出现较各成分单独存在时的肾损害发生的危险增加,且危险度随着合并成分数量的增加而上升。（5）BMI≥25、高胆固醇血症、高三酰甘油血症、高尿酸血症、糖尿病和高血压是慢性肾损害的危险因素。（6）轻度肾功能减退组BMI、TC、TG和尿酸较无肾损害组明显增高,BMI≥25、高胆固醇血症、高尿酸血症、糖尿病和高血压是发生轻度肾功能减退的危险因素。结论：（1）代谢综合征是包括轻度肾功能减退在内的继发性慢性肾损害的重要危险因素。（2）随着代谢综合征成分的增多慢性肾脏损害的危险随之增加,糖尿病和BMI增加是其中最重要的危险因素。

Clinical Study on the Role of Metabolic Syndrome in Secondary Chronic Renal Damage

Objective:Study of the metabolic syndrome on the impact of chronic kidney damage,including mild renal dysfunction.Methods:Retrospective analysis of 966 cases of clinical data in patients with metabolic syndrome.Results:(1)Patients with chronic impairment the age,BMI,TC,TG,uric acid levels were higher than those without chronic renal patients,while HDL levels were significantly lower than in patients with chronic kidney damage.(2)The prevalence of diabetes,hypertention coronary heart disease stroke in chronic renal damage is higher.(3)The patient with 2,3,4metabolic syndrome components the prevalence of chronic renal damage was significantly increased,With the increase in metabolic syndrome components and an upward trend.(4)The risk of kidney damage is higher in the combing of Diabetes,hypertention,BMI≥25 lipid abnormalities (ect,) than in the separation.(5)BMI≥25,hypercholesterolemia,hypertriglyceridemia hyperuricemia diabetes and hypertension are risk factors for chronic kidney damage.(6)The group with mild renal dysfunction BMI,TC,TG and uric acid is more increased than those without renal damage BMI≥25 hypercholesterolemia,hyperuricemia,diabetes and mild hypertension are risk factors for mild renal dysfunction.Conclusion:(1)Metabolic syndrome is an important risk factor to secondary chronic renal damage including Mild renal dysfunction.(2)With the increase in metabolic syndrome components the risk of chronic damage intensify,diabetes and increased BMI is one of the most important risk factor.