胃旁路术对非肥胖型2型糖尿病大鼠糖代谢的影响

目的:观察胃旁路术对非肥胖型2型糖尿病大鼠(GK大鼠)糖代谢的影响.方法:GK大鼠20只,Wistar大鼠10只,随机分为GK手术组、GK假手术组和Wistar假手术组,每组10只;手术组行胃旁路术;测定术前1周及术后第1、2、4、8、12周各组体质量、空腹血糖(FPG)、糖化血红蛋白(HbA1c)水平和血清胰岛素(INS)含量.结果:术后12周,GK手术组大鼠体质量由术前的(255.10±21.09)g上升到(364.55±25.73)g,FPG和HbA1c分别由术前的(11.36±1.14)mmol/L和(8.91±0.36)%下降到(8.36±0.62)mmol/L和(6.35±0.46)%,而血清INS由术前(32.76±2.37)μIU/mL上升到(55.14±5.45)μIU/mL.结论:胃旁路术可以明显降低GK大鼠的空腹血糖,改善糖代谢障碍.

Effect of Gastric Bypass Surgery on Glucose Metabolism of Non-obese Type 2 Diabetes Mellitus in Goto-Kakizaki Rats

Objective To investigate the influence of gastric bypass surgery on glucose metabolism in Goto-Kakizaki (GK) rats.Methods Twenty male GK rats and 10 male Wistar rats were randomized into 3 groups:GK operation,GK sham-operation and Wistar sham-operation groups,gastric bypass surgery was processed in the GK operation group.Body weight,fasting plasma glucose (FPG),glycosylated hemoglobin (HbA1c) level and serum insulin (INS) were monitored at 1 week before surgery and at the 1st,2nd,4th,8th and 12th week after surgery.Result In the GK operation group the weight increased from 255.10±21.09 g before surgery to 364.55±25.73 g,and the FPG decreased from 11.36±1.14 mmol/L before surgery to 8.36±0.62 mmol/L,and HbA1c decreased from 8.91±0.36%to 6.35±0.46% at the 12th week after surgery in GK operation rats.Meanwhile the serum INS increased from 32.76±2.37 μIU/mL before surgery to 55.14±5.45 μIU/mL at the 12th week after surgery in the GK operation rats,with statistical significance(P < 0.05).Conclusion Gastric bypass surgery can significantly reduce fasting plasma glucose levels,and improve glycometabolism in non—obese type 2 diabetes GK rats.