| 压力性尿失禁雌鼠模型的建立 |
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| 引用本文： | 王智勇,张瑞莉,韩前河,杨彦峰,魏金星,文建国. 压力性尿失禁雌鼠模型的建立[J]. 医药论坛杂志, 2009, 30(12): 9-10,13 |
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| 作者姓名： | 王智勇 张瑞莉 韩前河 杨彦峰 魏金星 文建国 |
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| 作者单位： | 郑州大学第一附属医院尿动力学中心,郑州市,450052;郑州大学第一附属医院泌尿外科;河南省高等学校临床医学重点学科开放实验室 |
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| 基金项目： | 河南省科技厅普通攻关项目(340600531410) |
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| 摘 要： | 目的建立压力性尿失禁动物模型,为压力性尿失禁的研究提供材料。方法30只健康雌性大鼠被随机平均分为实验组(15例)和对照组(15例),实验组切断阴部神经,对照组只游离不切断,所有大鼠行耻骨上膀胱置管,手术前后分别测定腹压漏尿点压(PALP)。结果2组术前PALP差异无统计学意义;对照组手术前后的PALP差异无统计学意义(P>0.05),而实验组手术前后PALP二者差异有统计学意义(P<0.05)。结论阴部神经切断是可以建立女性压力性尿失禁雌鼠模型的一种有效方法,该模型具有SUI发生率高、稳定性好的优点。
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| 关 键 词： | 压力性尿失禁 动物模型 漏尿点压 |
Establishment of A Rat Model for Stress Urinary Incontinence |
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| WANG Zhiyong,ZHANG Ruili,HAN Qianhe,et al Urodynamic Center,The First Affiliated Hospital of Zhengzhou University,Zhengzhou ,China. Establishment of A Rat Model for Stress Urinary Incontinence[J]. Journal of Medical Forum, 2009, 30(12): 9-10,13 |
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| Authors: | WANG Zhiyong ZHANG Ruili HAN Qianhe et al Urodynamic Center The First Affiliated Hospital of Zhengzhou University Zhengzhou China |
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| Affiliation: | WANG Zhiyong,ZHANG Ruili,HAN Qianhe,et al Urodynamic Center,The First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China |
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| Abstract: | Objective To explore the feasibility of cutting off the pudendal nerves to establish a rat model of female stress urinary incontinence(SUI).Methods A total of 30 healthy female SD rats were randomly allocated into 2 groups,namely control group(n=15) and bilateral PNT group(n=15).The abdominal leak point pressure(PALP) testing was performed.Bilateral pudendal Nerves were transected in PNT group and isolated only in the control group.PALP was measured again.Results In control group,the difference was not sign... |
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| Keywords: | Stress urinary incontinence Animal model Leak point pressure |
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