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| 土鳖虫纤溶活性蛋白抗小鼠血栓形成作用研究 | |
| 引用本文： | 李兴暖,韩雅莉. 土鳖虫纤溶活性蛋白抗小鼠血栓形成作用研究[J]. 中药药理与临床, 2008, 24(5) |
| 作者姓名： | 李兴暖 韩雅莉 |
| 作者单位： | 1. 九江学院医学院生理病生教研室,九江汕头大学医学院中心实验室,汕头,515041 2. 广东工业大学轻工化工学院,广州,510090 |
| 摘 要： | 目的:研究土鳖虫纤溶活性蛋白的抗凝、纤溶和抗血栓形成作用。方法:小鼠灌胃土鳖虫纤溶活性蛋白后,取血浆测定白陶土部分凝血活酶时间(KPTT)、凝血酶时间(TT)和凝血酶原时间(PT),测定组织型纤溶酶原激活剂(t-PA)和其抑制物(PAI)的活性;用角叉菜胶诱发小鼠体内血栓形成,测量尾部血栓形成的长度。结果:土鳖虫纤溶活性蛋白能够显著延长小鼠TT,使t-PA活性增强,同时抑制PAI的活性,显著抑制角叉菜胶所致的尾部血栓形成。结论:土鳖虫纤溶活性蛋白能部分抑制凝血途径,激活纤溶系统,抑制血栓形成。 |
| 关 键 词： | 土鳖虫 纤溶活性蛋白 抗凝 纤溶 血栓形成 |
The study of anti-thrombogenic effect of Eupolyphaga sinesis Walker fibrinolytic protein in mice |
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| Li Xingnuan,Han Yali. The study of anti-thrombogenic effect of Eupolyphaga sinesis Walker fibrinolytic protein in mice[J]. Pharmacology and Clinics of Chinese Materia Medica, 2008, 24(5) | |
| Authors: | Li Xingnuan Han Yali |
| Affiliation: | Li Xingnuan,Han Yali(College of Medical,Jiujiang University,Jiujiang,College of Medical,Shantou University,Shantou 515041) |
| Abstract: | Objective: To study the anticoagulative,fibrinolytic and anti-thrombogenic effect of Eupolyphaga sinesis Walker fibrinolytic protein(EFP).Methods: The different doses EFP were given mice in different groups,then kaolin partial thromboplastin time(KPTT),thrombin time(TT),prothrombin time(PT),tissue-type plasminogen activator(t-PA) and plasminogen inhibitor(PAI) activity were detected.Results :The TT of mice was markedly prolonged after administration EFP.The t-PA activity was elevated,and the PAI activity wa... |
| Keywords: | Eupolyphaga sinesis Walker fibrinolytic protein(EFP) anticoagulation fibrinolysis thrombosis |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |