| 细胞周期素依赖性蛋白激酶-5参与疼痛、阿片耐受 |
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| 引用本文： | 吴飞翔,吕欣,俞卫锋. 细胞周期素依赖性蛋白激酶-5参与疼痛、阿片耐受[J]. 国际麻醉学与复苏杂志, 2008, 29(3) |
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| 作者姓名： | 吴飞翔 吕欣 俞卫锋 |
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| 作者单位： | 第二军医大学附属东方肝胆外科医院麻醉科,上海,200438 |
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| 摘 要： | 疼痛及其治疗是临床上的一大难题,主要由于机制不明.Cdk5是一种特殊的细胞周期素依赖性激酶家族,几乎存在于整个中枢和外周神经系统的神经元内.Cdk5作为丝氨酸/苏氨酸激酶,可调节众多底物和蛋白,目前发现在疼痛信号通路及阿片耐受中具有重要作用,可能作为治疗疼痛的新方法,对其在疼痛通路及阿片耐受中作用的深入了解,将有助于解决这一难题.
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| 关 键 词： | 疼痛 耐受 阿片 吗啡 |
Cdk5 involved in pain and opioid tolerance |
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| WU Fei-xiang,LV Xin,YU Wei-feng. Cdk5 involved in pain and opioid tolerance[J]. international journal of anesthesiology and resuscitation, 2008, 29(3) |
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| Authors: | WU Fei-xiang LV Xin YU Wei-feng |
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| Abstract: | Pain therapy is a major clinical problem due to the unknown mechanisms. Cyclin- dependent kinases- 5 (Cdk5), a unique member of the cyclin -dependent kinases, expresses in almost entire central and peripheral neurons. Cdk5 ,as one of the set/Thr kinases, regulates many known substrates and proteins. More recently, Cdk5 has been implicated a role in nociceptive signaling and also the development of opioid tolerance, which makes it a new potential way to treat pain. |
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| Keywords: | Cdk5 |
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