| 绵毛黄芪苷和苦玄参苷的中枢抑制作用 |
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| 引用本文： | 张银娣,刘小浩,沈建平.绵毛黄芪苷和苦玄参苷的中枢抑制作用[J].南京医科大学学报,1990(1). |
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| 作者姓名： | 张银娣 刘小浩 沈建平 |
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| 作者单位： | 南京医学院药理教研室，江苏省中医研究所药理室，南京医学院药理教研室 |
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| 摘 要： | 报道了绵毛黄芪苷(SK)及其同类结构苦玄参苷(PIA)给予昆明种式BLC_(57)/1小鼠50mg/kg腹腔注射能明显延长硫贲妥钠的睡眠时间,用扭体法或热板法证实同量SK或PIA静脉注射能产生明显的镇痛作用。用格斗试验证实:同量SK或PIA腹腔注射可使小鼠格斗试验次数明显减少。提示两种苷可能具有中枢镇静、镇痛和安定作用;此类中枢抑制作用说明四环三萜皂苷类具有药用价值的前景。
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| 关 键 词： | 绵毛黄芪苷Ⅺ 苦玄参苷 镇痛 镇静 安定 |
DEPRESSIVE EFFECTS OF SK AND PIA ON CNS IN MICE |
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| Zhang Yindi.DEPRESSIVE EFFECTS OF SK AND PIA ON CNS IN MICE[J].Acta Universitatis Medicinalis Nanjing,1990(1). |
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| Authors: | Zhang Yindi |
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| Institution: | Zhang Yindi |
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| Abstract: | Astrasieversinin(SK) and Picfeltarraenin IA(PIA), isolated from astragalus sieversianus pull and picriafel-tarrae lour by workers of Shanghai Institute of Organic Chemistry, when given 50 mg (SK or PLA)/kg i.p. could prolong the sleeping time induced by thiopental in different species of mice. The analgesic effect of the two compounds at the same dose was also shoun in mice by using body twist and heat-plate methods. Also weak tranquilizing effect of those two compounds was demonstrated in mice by hostility test. |
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| Keywords: | astrasieversianin picfeltarraenin sedation analgesia tranquilization |
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