利培酮与氯丙嗪治疗精神分裂症的随机双盲比较

目的 :比较利培酮与氯丙嗪对精神分裂症的疗效。方法 :精神分裂症 6 6例 ,随机分为 2组。利培酮组男性 2 3例 ,女性 10例 ,年龄 (38±s 10 )a ,予利培酮 (4 .4± 1.1)mg·d- 1,po ,bid ;氯丙嗪组男性 2 2例 ,女性 11例 ,年龄 (38± 12 )a ,予氯丙嗪(4 56± 98)mg·d- 1,po ,bid。疗程 12wk。用阳性和阴性症状量表及副反应量表评定疗效和不良反应。结果 :利培酮组与氯丙嗪组总有效率分别为82 %和 76 %。治疗前后阴性量表分 2组间差值比较 ,差异有非常显著意义 (P <0 .0 1)。治疗期间未发现严重不良反应。结论 :利培酮与氯丙嗪对精神分裂症的疗效相当 ,但对阴性症状明显优于后者。

Risperidone vs chlorpromazine in treating schizophrenia: a randomized double-blind study

AIM: To compare the effects of risperidone and chlorpromazine in treating schizophrenia. METHODS: Sixty six schizophrenia patients were randomly assigned to two groups, risperidone group [M 23, F 10; age (38± s 10) a] and chlorpromazine grorp [M 22, F 11; age (38±12) a]. They were given orally risperidone (4.4±1.1) mg·d -1 or chlorpromazine (456±98) mg·d -1 respectively for 12 wk. Symptom improvement and adverse reactions were rated with PANSS and TESS. RESULTS: The total effective rate of risperidone or chlorpromazine was 82% and 76%. The scores of negative syndrome scale of risperidone group were decreased more significantly than chlorpromazine group ( P < 0.01 ). The adverse reactions were mild. CONCLUSION: The improvement of positive syndrome are similar within both groups, but for negative syndrome, risperidone is superior to chlorpromazine.