Caveolin-1和nm23在乳腺癌中的表达及意义

［摘要］ 目的 探讨Caveolin-1及nm23蛋白在乳腺癌及正常乳腺组织中的表达及临床意义。方法：采用免疫组织化学法，检测86例乳腺癌及20例正常乳腺组织中Caveolin-1及nm23蛋白的表达,并分析其与患者临床病理特征的关系。结果 Caveolin-1和nm23在乳腺癌中的表达明显低于正常乳腺组织(P＜0.05）；Caveolin-1和nm23在乳腺癌中的表达存在正相关(r=0.653，P＜0.01)。Caveolin-1表达与淋巴结转移及临床分期有关(P＜0.05)，与患者年龄、组织分级及肿瘤大小无关(P＞0.05)。nm23表达与淋巴结转移、组织分级及临床分期有关(P＜0.05)，与患者年龄、肿瘤大小无关(P＞0.05)。结论 Caveolin-1及nm23表达缺失可能是乳腺癌发生、发展以浸润转移的重要因素之一，nm23的缺失可能下调Caveolin-1的活性，联合检测对判断乳腺癌预后有指导意义。

Expression of Caveolin-1 and nm23 in invasive ductal carcinoma of breast and their clinical Significance

［Abstract］Objective：To investigate the expression of Caveolin-1 and nm23 in invasive ductal carcinoma of breast and normal breast tissues, and to explore their clinical Significance.Methods：Immunohistochemical EnVision method was used to detect the expression of Caveolin-1 and nm23 in 86 cases of breast cancer tissues and 20 cases of normal breast tissues. The correlation of Caveolin-1 and nm23 with clinical pathologic features of breast cancer was analyzed．Results：The expression of Caveolin-1 and nm23 in breast cancer was significantly lower than in normal breast tissue(P＜0.05). Caveolin-1 expression was positive correlation with nm23 protein in breast cancer(r=0.653，P＜0.01). Caveolin-1 expression in breast cancer with lymph node metastasis and clinical stage, but not with age, histological grade and tumor size(P＞0.05). nm23 expression in breast cancer with lymph node metastasis, histological grade and clinical stage, but not with patient age and tumor size(P＞0.05)．Conclusion：Caveolin-1 and nm23 gene may be breast cancer, invasion and metastasis development of one of the important factors, and the loss of nm23 might reduce the activity of Caveolin-1.combined detection of judging the prognosis of breast cancer guide.