| BRAFV600E突变与甲状腺乳头状癌诊治研究进展 |
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| 引用本文： | 苏艳军,刁畅,张建明,程若川. BRAFV600E突变与甲状腺乳头状癌诊治研究进展[J]. 国际外科学杂志, 2011, 38(2): 104-109. DOI: 10.3760/cma.j.issn.1673-4203.2011.02.011 |
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| 作者姓名： | 苏艳军 刁畅 张建明 程若川 |
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| 作者单位： | 昆明医学院第一附属医院胃肠与甲状腺外科,云南省甲状腺外科临床研究中心,昆明,650032 |
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| 摘 要： | BRAFV600E突变是甲状腺乳头状癌中最常见的基因突变，在甲状腺乳头状癌的发生发展和浸润转移中发挥了重要作用。BRAFV600E突变对甲状腺乳头状癌的诊断和预后判断有重要的价值，针对BRAF蛋白激酶及其下游效应器的靶向抑制剂治疗是BRAFV600E突变甲状腺癌治疗的新方向。
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| 关 键 词： | BRAF突变 甲状腺乳头状癌 诊断 治疗学 |
Progress in the BRAFV600E mutation and papillary thyroid carcinoma |
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| SU Yan-jun,DIAO Chang,ZHANG Jian-ming,CHENG Ruo-chuan. Progress in the BRAFV600E mutation and papillary thyroid carcinoma[J]. International Journal of Surgery, 2011, 38(2): 104-109. DOI: 10.3760/cma.j.issn.1673-4203.2011.02.011 |
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| Authors: | SU Yan-jun DIAO Chang ZHANG Jian-ming CHENG Ruo-chuan |
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| Abstract: | BRAFV600E mutation is the most common genetic alteration in the papillary thyroid carcinoma.It plays an important role in the tumorigenesis,invasiveness and metastasis of the papillary thyroid carcinoma.Testing of BRAFV600E mutation is of great value in diagnosis,which also can be used as a prognostic maker of papillary thyroid cancer.Inhibitors treatment targeted to BRAF kinase and its downstream effectors is a new area in the treatment of BRAFV600E mutated thyroid cancer. |
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| Keywords: | BRAF mutation Papillary thyroid carcinoma Diagnosis Therapeutics |
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