FcγRⅡb基因多态性与常见风湿病发病相关性研究进展

FcγRⅡb属FcγR中的抑制性受体,编码基因位于染色体1 q23.多项研究认为其基因多态性与系统性红斑狼疮(systemic lupus erythematosus,SLE),类风湿关节炎(rheumatoid arthritis,RA),强直性脊柱炎(ankylosing spondylitis,AS)等风湿免疫病相关.而在不同种族的人群中研究结果不同,但仍可以认为,FcγRⅡb基因多态性在某些人群的常见风湿免疫病发病过程中起重要作用.

Abstract：

IgG Fc receptor Ⅱ b ( FcγR Ⅱ b ) is an inhibitory Fc receptor expressed on B cells and myeloid cells, and its coding gene is located on Chromsome 1 q23. These receptors are very important for the regulation of body' s responses to infection. The reduced expression of function of these receptors may predispose to autoimmunity. The FcγR Ⅱ b gene polymorphisms affect the affinity with which FcRs interact with immunoglobulin molecules. Correlation of the FcγR Ⅱ b polymorphisma with susceptibility of common rheumatic diseases, such as Systemic Lupus Erythematosus ( SLE ) , Rheumatoid Arthritis ( RA ) ,Ankylosing Spondylitis (AS) , has been reported in various populations, but the results were inconsistent.