氧化应激、氧化低密度脂蛋白和脂蛋白相关磷脂酶A2与动脉粥样硬化

氧化应激是动脉粥样硬化早期的一个重要危险因素,涉及线粒体损伤、自由基释放,脂质过氧化、磷脂酶激活以及炎症介质释放等多种病理生理学过程.越来越多的研究表明,氧化应激、氧化低密度脂蛋白和脂蛋白相关磷脂酶A2在动脉粥样硬化的发生和发展中起着重要的作用.因此,探讨其相互关系,有助于加深动脉粥样硬化的认识,并采取针对性预防.

Oxidative stress, oxidized low density lipoprotein, lipoprotein-associated phospholipase A2 and atherosclerosis

Oxidative stress is 811 important risk factor for premature athcrosclcrosis.Itis involved in a variety of pathophysiological processes,including mitochondrial damage,freeradical release,lipid peroxidation,phospholipase activation,and infl~niatory modiator release.A growing body of research suggests that oxidative stress,oxidized low density hpoprotein,andlipoprotein-associated phospholipase A2 Play important roles in the occurrence and developmentof athcrosclcrosis.Therefore,investigating their relationship contributes to deepen theunderstanding of athcrosclerosis and take appropriate preventive measures.