骨骼肌线粒体异常在胰岛素抵抗形成中的作用

胰岛素抵抗及其相关疾病与机体的各种代谢异常密切相关.线粒体是调控代谢通路的重要细胞器,其功能的改变可对机体代谢产生极大影响.骨骼肌是胰岛素刺激葡萄糖利用的主要器官,同时也是富含线粒体和依赖氧化磷酸化供能的组织.因此,骨骼肌线粒体异常可能与胰岛素抵抗高度相关,其机制有待阐明.

The role of skeletal muscle mitochondrial dysfunction in insulin resistance

Insulin resistance and its related diseases are closely related to metabolic abnormalities.Mitochondrion is an important organelle which is responsible to regulate the metabolic pathways,and mitochondria dysfunction may cause significant impact on the metabolism of the body. Skeletal muscle,which is rich in mitochondria and has a high reliance on oxidative phosphorylation for ATP, is the principal tissue responsible for insulin-stimulated glucose disposal. Therefore, skeletal muscle mitochondrial dysfunction may play an important role in the pathogenesis of insulin resistance,but the mechanism remains to be clarified.