| 转化生长因子-β参与CD4^＋CD25^＋调节性T细胞诱导的发育研究进展 |
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| 引用本文： | 张伯彬,尹辉,古宏标. 转化生长因子-β参与CD4^＋CD25^＋调节性T细胞诱导的发育研究进展[J]. 国际免疫学杂志, 2011, 34(2): 139-142. DOI: 10.3760/cma.j.issn.1673-4394.2010.02.015 |
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| 作者姓名： | 张伯彬 尹辉 古宏标 |
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| 作者单位： | 1. 广东药学院病理生理学教研室,广州,510006
2. 广东药学院微生物与免疫学教研室,广州,510006 |
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| 摘 要： | CD4^＋CD25^＋调节性T细胞（CD4^＋CD25^＋Treg）足一类具有免疫调节功能的淋巴细胞，在维持机体免疫耐受和免疫应答稳态方面发挥重要作用。转化生长因子β（TGF—β）与CD4^＋CD25^＋Treg的发育分化和功能有着密不可分的关系，虽然作用机理尚不完全明了，但其重要性毋情置疑。
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| 关 键 词： | TGF—β Foxp3 CD4^＋CD25^＋调节性T细胞 诱导 |
Research advances of TGF- to the induction of CD4 + CD25 + regulatory T cells |
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| ZHANG Bo-bin,YIN Hui,GU Hong-biao. Research advances of TGF- to the induction of CD4 + CD25 + regulatory T cells[J]. International Journal of Immunology, 2011, 34(2): 139-142. DOI: 10.3760/cma.j.issn.1673-4394.2010.02.015 |
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| Authors: | ZHANG Bo-bin YIN Hui GU Hong-biao |
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| Affiliation: | ( Department of Pathophysiology, Guangdong Pharmaceutical University, Guangzhou 510006, China) |
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| Abstract: | CD4 + CD25 + regulatory T cells (CD4 + CD25 + Treg) are a type of T lymphocytes that function in immune regulation and play a major role in maintaining the homeostasis of immune tolerance and immune response. Transforming growth factor β (TGF-β), an important cytokine, plays a critical role in the development, differentiation and function of Treg. However, the exact mechanism throught which TGF-β funcitions has not been completely understood. The role and influencing factors of TGF-3 to the development and differentiation of Treg are summarized in this review. |
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| Keywords: | Foxp3 |
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