匙羹藤对2型糖尿病大鼠胰岛素抵抗及脂肪细胞因子的影响

目的 观察匙羹藤(gymnema Sylvestre,GS)对2型糖尿病大鼠糖脂代谢及血清脂肪细胞因子的影响.方法 采用高脂饲料喂养加腹腔注射小剂量STZ的方法制备2型糖尿病动物模型,按随机数字表法分为模型组、GS高剂量组、GS低剂量组、吡格列酮组.灌胃治疗4周后检测,空腹血糖(FBG)、血清胰岛素(INS)、甘油三酯...

Effects of Gymnema Sylvestre on glucose-lipid metabolism and adipo-cytokines in Type 2 DM Rats

Objective To investigate the effects of Gymnema Sylvestre on glucose-lipid metabolism and adipo-cytokines in T2 DM Rats. Methods The T2 DM rats induced by high lipid diet and small dosage intraperitoneal injection of STZ, were randomly divided into model group (DM), high dose GS group (GSH),low dose GS group (GSL) and pioglitazone group (Pio, n= 8 in each). Each group has a DM inserted by gavage.Four weeks later, the levels of fasting blood glucose (FBG), serum insulin (INS), blood lipid (TG, CHOL, HDL and LDL), free fatty acdi (FFA), TNF-α, C-reactive protein (CRP)and adiponcetin(ADPN) were detected.Results Compare to model group, the levels of FBG, INS, Blood lipid, FFA, TNF-α and CRP were decreased in GSH and Pioglitazone groups, adiponcetin were increased in GSH and Pioglitazone groups, except in GSL group. Conclusion GS can improve the glucose-lipid metabolism disorder and insulin resistance in type 2diabetic mellitus rats. The mechanisms may be the amelioration of inflammatory response and adipocytokines,but still need further study to prove the conclusions.