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| 芬太尼联合七氟烷后处理对离体大鼠缺血/再灌注心功能的影响 | |
| 引用本文： | 于静,张冯江,杨美娟,何伟,郁丽娜,严敏. 芬太尼联合七氟烷后处理对离体大鼠缺血/再灌注心功能的影响[J]. 国际麻醉学与复苏杂志, 2011, 32(1): 27-31. DOI: 10.3760/cma.j.issn.1673-4378.2011.02.009 |
| 作者姓名： | 于静 张冯江 杨美娟 何伟 郁丽娜 严敏 |
| 作者单位： | 1. 徐州医学院江苏省麻醉学重点实验室,221002 2. 浙江大学医学院附属第二医院麻醉科 |
| 基金项目： | 浙江省自然基金杰出青年团队项目，国家自然基金面上项目，浙江省科技厅钱江人才计划 |
| 摘 要： | 目的 研究芬太尼联合七氟烷后处理对离体大鼠缺血/再灌注(ischemia/reperfusion,I/R)心脏心功能的影响.方法 建立离体大鼠心脏缺血40 min,再灌注120 min模型.根据再灌注开始10 min的不同处理,使用随机数字表法将实验动物随机分为4组(n=10):I/R对照组(Con),七氟烷后处理组(... |
| 关 键 词： | 七氟烷 芬太尼 后处理 缺血/再灌注 心功能 |
The effects of fentanyl combined with sevoflurane postconditioning on myocardial functions of isolated ischemia-reperfused rat heart |
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| Abstract: | Objective To investigate the effects of fentanyl combined with sevoflurane postconditioning on myocardial functions of isolated ischemia-reperfused rat hearts.Methods Depending on the different treatments given at 10 min after reperfusion started,isolated perfused rat hearts were randomly assigned to the following four groups(n=10):ischemia/reperfusion (Con),sevoflurane postconditioning (SPC),fentanyl postconditioning (Fent),and fentanyl plus sevoflurane postconditioning (Fent+SPC). All of the hearts were subjected to 40 min global myocardial ischemia and 120 min reperfusion. Left ventricular systolic pressure(LVSP),Left ventricular developed pressure (LVDP),maximum increasing rate of LVDP(+dp/dt),maximum decreasing rate of LVDP (-dp/dt),heart rate (HR) and coronary flow (CF) were recorded. Lactate dehydrogenase(LDH) was measured. Infarct size was determined by triphenyltetrazolium chloride staining.Results LVSP,LVDP,±dp/dt,and CF were higher in SPC group than in Con group at all points of reperfusion (P＜0.05). Compared with SPC group,the Fent and Fent+SPC group (P＜0.05) had significantly improved LVSP and LVDP at the beginning 15 min of reperfusion,which were gradually reduced and lower than SPC group at all time points after 60 min of reperfusion. There were no significant diffirences in HR among four groups. The values of ±dp/dt and CFin Fent and Fent+SPC group were dramatically improved in the early stage of reperfusion(P＜0.05),while similar to the Con group at the end of reperfusion. The SPC,Fent and Fent+SPC group had a significantly reduced LDH release and decreased infarct size compared with the Con group [(22.7±2.3)%, (20.6±2.8)%, (21.3±3.3)% vs.(45.8±3.2)%,respectively; P＜0.05).Conclusion Sevoflurane postconditioning improves myocardial |
| Keywords: | Sevoflurane Fentanyl Postconditioning Ischemia/Reperfusion Myocardial function |
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