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| 脂肪细胞脂肪酸结合蛋白与糖尿病肾病早期的相关性研究 | |
| 引用本文： | 吴迁,王海燕. 脂肪细胞脂肪酸结合蛋白与糖尿病肾病早期的相关性研究[J]. 中国实用医药, 2011, 6(5): 1-2 |
| 作者姓名： | 吴迁 王海燕 |
| 作者单位： | 青岛市第八人民医院,266071 |
| 摘 要： | 目的探讨脂肪细胞脂肪酸结合蛋白(FABP4)与糖尿病肾病早期的相关性。方法实验分为糖尿病肾病早期组46例和正常对照组40例,用ELISA方法检测FABP4,检测空腹血糖(FBP)、糖化血红蛋白(HbA1c)、胰岛素、血脂和肌酐(Scr),根据公式计算胰岛素敏感指数(ISI)和肾小球滤过率(eG-FR),用SPSS13.0统计软件进行统计分析。结果①糖尿病肾病组的体重指数(BMI)、FBG、三酰甘油(TG)、胆固醇(TC)、Scr和FABP4均较对照组增加(P<0.05),而ISI和eGFR则明显降低(P<0.05);②Spearman相关分析显示糖尿病肾病组血浆FABP4与BMI、FBG、HbA1c、TG、Scr正相关,r分别为0.16、0.17、0.22、0.20、0.31(P<0.05)。而与ISI和eGFR负相关r分别为-0.32(P<0.01)、-0.44(P<03.01)。结论糖尿病肾病早期患者的FABP4水平升高,与肾功能具有负相关性。 |
| 关 键 词： | 脂肪细胞脂肪酸结合蛋白 糖尿病肾病 相关性研究 |
Study on plasma fatty acid-binding protein 4 and renal dysfunction in the early stages of drabetre nephropathy |
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| WU Qian,WANG Hai-yan. Study on plasma fatty acid-binding protein 4 and renal dysfunction in the early stages of drabetre nephropathy[J]. China Practical Medical, 2011, 6(5): 1-2 | |
| Authors: | WU Qian WANG Hai-yan |
| Affiliation: | WU Qian,WANG Hai-yan.Qingdao Eighth People's Hospital,Shandong 266071,China |
| Abstract: | Objective To evaluate whether plasma FABP4 is associated with renal dysfunction in the early stages of drabetre nephropathy.Methods 46 cases type 2 diabetic patients with microalbuminuria and 40 age-matched healthy nondiabetic controls were recruited.FABP4 levels were analyzed with enzyme-linked immunosorbent assay.Fasting blood glucose(FBG),fasting insulin,HbA1c,serum lipids and plasma creatinine were analyzed.The insulin sensitivity index(ISI)was applied to assess the status of insulin resistance,and we a... |
| Keywords: | Fatty acid-binding protein 4 Diabetic nephropathy Correlation studies |
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