| 白细胞介素21抗肿瘤作用的研究进展 |
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| 引用本文： | 田永菊,崔保霞. 白细胞介素21抗肿瘤作用的研究进展[J]. 肿瘤, 2010, 30(3). DOI: 10.3781/j.issn.1000-7431.2010.03.018 |
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| 作者姓名： | 田永菊 崔保霞 |
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| 作者单位： | 山东大学齐鲁医院妇产科,济南,250012 |
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| 基金项目： | 山东省优秀中青年科学家科研奖励基金计划 |
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| 摘 要： | 白细胞介素21(interleukin-21, IL-21) 是新近发现的具有免疫调节活性的细胞因子, 属于IL-2细胞因子家族新成员,主要由活化的CD4~+ T 细胞分泌,IL-21与其受体结合后可调节T细胞、自然杀伤(natural killer,NK)细胞和B细胞的增殖、分化和功能,有效增强机体的天然免疫及获得性免疫.在多种肿瘤模型中已证实,IL-21具有抗肿瘤活性,且Ⅱ期临床试验正在转移性黑素瘤和肾细胞癌中进行,其在恶性肿瘤治疗方面具有广泛的应用前景.本文对IL-21的抗肿瘤作用及其联合其他药物在未来肿瘤免疫治疗中的应用前景进行综述.
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| 关 键 词： | 肿瘤 白细胞介素-21 T淋巴细胞 B淋巴细胞 |
The research progress of anti-tumor effects of interleukin-21 |
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| TIAN Yong-ju,CUI Bao-xia. The research progress of anti-tumor effects of interleukin-21[J]. Tumor, 2010, 30(3). DOI: 10.3781/j.issn.1000-7431.2010.03.018 |
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| Authors: | TIAN Yong-ju CUI Bao-xia |
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| Affiliation: | TIAN Yong-ju,CUI Bao-xia(Department of Obstetrics , Gynecology,Qilu Hospital,Sh,ong University,Ji'nan 250012,China) |
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| Abstract: | Interleukin-21 (IL-21) is a recently discovered cytokine with immunomodulatory activity. It is a new member of the IL-2 family and mainly secreted by the activated CD4~+ T cells. IL-21 can promote proliferation, differentiation and function of T cells, natural killer (NK) cells, and B cells after binding with its receptor, thereby effectively strengthen the innate immunity and acquired immunity. The antitumor activity of IL-21 has been demonstrated in several tumor models. Its phase Ⅱ trials is being carried out in metastatic melanoma and renal cell carcinoma. IL-21 has a broad application prospects in the treatment of malignant tumors. Here, we review the anti-tumor effects of IL-21 and the application foreground of combination of IL-21 with other drugs in future tumor immunotherapy. |
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| Keywords: | Neoplasms Interleukin-21 T-lymphocytes B-lymphocytes |
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