| 应用均匀设计考察 2-氯-4-氨基-6,7-二甲氧基喹唑啉合成工艺 |
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| 引用本文： | 徐莉英 金冲. 应用均匀设计考察 2-氯-4-氨基-6,7-二甲氧基喹唑啉合成工艺[J]. 沈阳药科大学学报, 1997, 14(2): 133-134,15 |
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| 作者姓名： | 徐莉英 金冲 |
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| 作者单位： | 沈阳药科大学药物研究所 |
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| 摘 要： | ２－氯－４－氨基－６，７－二甲氧基喹唑啉是合成一系列喹唑啉类α１受体阻滞剂的重要中间体．应用均匀设计考察合成工艺中氧化反应，使其收率由原来的４５％提高到６０％．
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| 关 键 词： | 2-氯-4-氨基-6，7-二甲氧基喹唑啉；均匀设计；合成工艺 |
Investigation of the Synthetic Technique of 2 Chloro 4 Amino 6,7 Dimetoxyquinazoline with Uniform Design |
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| Xu Liying,Zhang Xiaoqing,Jin Chong. Investigation of the Synthetic Technique of 2 Chloro 4 Amino 6,7 Dimetoxyquinazoline with Uniform Design[J]. Journal of Shenyang Pharmaceutical University, 1997, 14(2): 133-134,15 |
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| Authors: | Xu Liying Zhang Xiaoqing Jin Chong |
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| Abstract: | Chloro 4 amino 6,7 dimethoxyquinazoline is an important intermedium of a series of α 1 adrenoceptor antagonists of quinazolines.Uniform design was applied in its technoloqical study and the yield was increased from 45% to 60%. |
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| Keywords: | chloro 4 amiino 6,7 dimethoxyquinazoline uniform design synthetic technique |
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