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Diffusion tensor imaging of the inferior colliculus and brainstem auditory-evoked potentials in preterm infants
Authors:Milla Reiman  Riitta Parkkola  Reijo Johansson  Satu K. Jääskeläinen  Harry Kujari  Liisa Lehtonen  Leena Haataja  Helena Lapinleimu  PIPARI Study Group
Affiliation:(1) Department of Paediatrics, Turku University Central Hospital, Vaha-Hameenkatu 1 A 6, Turku, 20500, Finland;(2) Department of Radiology and Turku PET Centre, Turku University Central Hospital, Turku, Finland;(3) Department of Otorhinolaryngology, Turku University Central Hospital, Turku, Finland;(4) Department of Clinical Neurophysiology, Turku University Central Hospital, Turku, Finland;(5) Department of Pathology, Turku University Central Hospital, Turku, Finland;(6) Department of Paediatric Neurology, Turku University Central Hospital, Turku, Finland
Abstract:
Background  Preterm and low-birth-weight infants have an increased risk of sensorineural hearing loss. Brainstem auditory-evoked potentials (BAEP) are an effective method to detect subtle deficits in impulse conduction in the auditory pathway. Abnormalities on diffusion tensor imaging (DTI) have been shown to be associated with perinatal white-matter injury and reduced fractional anisotropy (FA) has been reported in patients with sensorineural hearing loss. Objectives  To evaluate the possibility of a correlation between BAEP and DTI of the inferior colliculus in preterm infants. Materials and methods  DTI at term age and BAEP measurements were performed on all very-low-birth-weight or very preterm study infants (n=56). FA and apparent diffusion coefficient (ADC) of the inferior colliculus were measured from the DTI. Results  Shorter BAEP wave I, III, and V latencies and I–III and I–V intervals and higher wave V amplitude correlated with higher FA of the inferior colliculus. Conclusion:  The association between the DTI findings of the inferior colliculus and BAEP responses suggests that DTI can be used to assess the integrity of the auditory pathway in preterm infants.
Keywords:MRI  Brain  Diffusion tensor imaging  Preterm infant
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