谷胱甘肽转硫酶T1基因型与溃疡性结肠炎易感性的关系

目的:探讨谷胱甘肽转硫酶(GST)T1基因型与中国浙江汉族人群溃疡性结肠炎(UC)易感性的关系.方法:应用聚合酶链反应技术检测99例溃疡性结肠炎(UC)患者和140例健康对照中的GSTT1基因型,采用χ2检验,分析比较GSTT1基因型在UC患者和健康人群中的分布差异.结果:GSTT1(-)基因型频率在UC组和对照组分布有显著性差异(64.7% vs 47.1%,P=0.007,OR=2.050,95%CI:1.208-3.480);根据UC临床特征进一步分层分析,GSTT1(-)基因型在远端UC中的分布频率高于广泛结肠UC(71.8%vs 31.3%,P=0.002);GSTT1(-)基因型与UC病情严重程度无关(P＞0.05).结论:GSTT1基因型与中国浙江汉族人群UC相关.

Association between genetic polymorphism of glutathione S-Transferase T1 and the susceptibility to ulcerative colitis

AIM: To investigate the association between the genetic polymorphism of glutathione S-Transferase T1 and the susceptibility to ulcerative colitis.METHODS: Polymerase chain reaction (PCR) was used to study the genetic polymorphisms of GSTT1 gene, then the discrepancies of GSTT1 gene polymorphism between the patients with ulcerative colitis and the healthy controls were analyzed using chi-square test.RESULTS: The frequency of null genotype for GSTT1 was significantly higher in the patients with ulcerative colitis than that in the controls (64.7% vs 47.1%, P = 0.007, OR = 2.050, 95%CI: 1.208-3.480). Further analysis showed that the frequency of GSTT1 null genotype was also higher in the patients with distal colitis than thatin the cases with total colitis (71.8% vs 31.3%, P = 0.002, OR=5.408, 95%CI: 1.698-17.231). There was no correlation between the frequency of GSTT1 null genotype and the severity degree of ulcerative colitis (P> 0.05).CONCLUSION: GSTT1 genotype is closely cor-related with the incidence of ulcerative colitis in Han Chinese of Zhejiang Province.