| 视黄酸对大鼠肝微粒体混合功能氧化酶系活性的影响 |
| |
| 引用本文： | 阎熙丰,王殿鸿,任永忠,吴治成,张海鹏. 视黄酸对大鼠肝微粒体混合功能氧化酶系活性的影响[J]. 中国医科大学学报, 1988, 0(2) |
| |
| 作者姓名： | 阎熙丰 王殿鸿 任永忠 吴治成 张海鹏 |
| |
| 作者单位： | 中国医科大学生物化学教研室(阎熙丰，王殿鸿，任永忠，吴治成)，中国医科大学生物化学教研室(张海鹏) |
| |
| 摘 要： | 本文以[~3H]-苯为茈底物,观察了维生素A的衍生物视黄酸对大鼠肝微粒体混合功能氧化酶系中的环氧化物酶、环氧化物水化酶及芳烃羟化酶活性的影响。用液体闪烁仪检测各酶催化所生成的[~3H]-苯芘环氧化物,[~3H]-苯芘羟化物及3-羟基苯芘的生成量。结果发现,视黄酸对环氧化物酶活性有明显的抑制作用,并用氰化钾抑制实验得到进一步证实。本实验对阐明维生素A及其衍生物的抗癌机理具有一定的意义。
|
| 关 键 词： | 衍生物 混合功能氧化酶 环氧化物酶 K区 7、8二氢二醇9、10环氧苯茈 |
EFFECT OF RETINOIC ACID ON THE ACTIVITY OF MIXEDFUNCTLON OXIDASE FROM RAT-LIVER MICROSOME |
| |
| Yan Xifong,et al. EFFECT OF RETINOIC ACID ON THE ACTIVITY OF MIXEDFUNCTLON OXIDASE FROM RAT-LIVER MICROSOME[J]. Journal of China Medical University, 1988, 0(2) |
| |
| Authors: | Yan Xifong et al |
| |
| Affiliation: | Department of Biochemistry |
| |
| Abstract: | Effects of retinoic acid on mixed-function on oxidase (epoxidase; epoxide hydrase; aryl hydrocarbon hydroxylase) which catalyze ~3H-Benzo (a) pyrene (BP) have been investigated ~3H-epoxids-BP, ~3H-dihydrcdiols-BP, ~3H-3-hyd-roxy-BP were determined with liquid scintillator. It was discovered that the activity of epoxidase was inhibited obviously by retinoic acid This was proved by inhibition experiment with potassium cyanide The results of the experiment have certain significance for revealing anticarcinogenic mechanism of vitamin A and its analogs |
| |
| Keywords: | Analog Mixed-function oxidase Epoxidase 7.8-dihydrodiol-9.10-epoxid-benzo (a) pyrene K-region |
| 本文献已被 CNKI 等数据库收录！ |
