服用他汀类药物与慢性心力衰竭患者认知功能关系的研究

目的探讨他汀类药物治疗对慢性心衰患者认知功能的影响。方法入选70例NYHAⅡ～Ⅳ级、左室射血分数<45%的慢性心衰患者为观察对象。其中连续服用他汀类药物3个月的35例慢性心衰患者进入他汀组,35例未服用他汀类药物的慢性心衰患者进入对照组。使用简易智能量表(Mini-Mental State Examina-tion,MMSE)评估两组入选时及入选3个月后的认知功能情况。结果他汀组与对照组在筛选及3个月后随访时,MMSE评分差异无统计学意义(P=0.78,P=0.77);两组间随访前后认知功能障碍比率比较差异无统计学意义(P=0.75,P=0.38);两组内入选及随访认知功能障碍比率比较差异无统计学意义(P=0.74,P=0.57)。结论本研究未能发现他汀类药物可改善慢性心衰患者认知功能,提示短期服用他汀类药物不能改善慢性心衰患者认知功能。

Relationship between statins taking and cognitive function in patients with chronic heart failure

Objective To identify the effect of statins taking on cognitive function in patients with chronic heart failure. Methods 70 patients with chronic heart failure(NYHA Ⅱ～Ⅳ),whose left ventricular ejection fractions were lower than 45%,were included.35 patients who had continuously taken statins for 3 months were enrolled in the statins therapy group,and the others who had not taken statins were enrolled in the control group.Then Mini-Mental State Examination(MMSE)were used to evalue the cognition function at the time of screening and after 3 months follow-up. Results There was no significant difference in MMSE scores between statins therapy group and control group at the time of screening(P=0.78)and after 3 months follow-up(P=0.77).The ratio of cognition impairment had no significant differentce between the two groups(P=0.74,P=0.57).In each group,there was no significant difference in MMSE scores at the time of screening and after 3 months follow-up(P=0.74,P=0.57). Conclusion The study has failed to prove that statins could improve the cognitive function of patients with chronic heart failure,suggests that short-term statins therapy could not improve cognitive function in patients with chronic heart failure.