西咪替丁治疗危重症新生儿并发上消化道出血42例

目的:观察西咪替丁治疗危重症新生儿并发上消化道出血的疗效。方法:将 83例患儿随机分为两组。两组均在积极治疗原发病的同时,给以 1%碳酸氢钠洗胃,凝血酶400U经胃管注入胃内,每6h一次,出血量多者输新鲜血。治疗组42例,在此基础上加用西咪替丁3~5mg/kg静滴,每6~8h1次。结果:治疗组总有效率为 92.9%(39/42),对照组总有效率为 70.7%(29/41),P＜0.01。结论:西咪替丁治疗危重症新生儿并发上消化道出血疗效显著,未见明显副作用。

Cimetidine in treating upper alimentary canal hemorrhage after critical neonates in 42 cases

Objective: To observe the efficacy of cimetidine in treating critical neonates complicated with upper alimentary canal hemorrhage. Methods: 83 cases of critical neonates complicated with upper alimentary canal hemorrhage were randomly divided into two groups, while treated the protopathy actively, two groups were washed out the stomach with 1 % dicarbonate, poured thrombin 400 unit into stomach through stomach tube and accepted metachysis in case of massive hemorrhage, cimtetidine group (n = 42) received cimetidine 3 ~ 5 mg/kg, iv drip, once every six to eight hours. Results: The total response rates of the control and cimetidine groups were 70. 7% and 92. 9% , respectively( P < 0. 01) . Conclusion: Cimetidine is efiective in treating upper alimentary canal hemorrhage alter critical neonates.