抑郁症的事件相关脑电位P300实验研究

目的探讨抑郁症听觉事件相关电位P300的变化特点。方法对35例抑郁症患者和31名健康成年人，应用美国NieoletBravo脑诱发电位仪进行P300检测。结果与正常组相比，抑郁症组Oz点P3潜伏期延迟正常组（315±29）ms，抑郁症组（341±31）ms，t=3．50，P〈0．01]，P2潜伏期延迟正常组（165±19）ms，抑郁症组（175±21）ms，t=2．02，P〈0．05]，P3波幅降低正常组（9．5±6．1）μV，抑郁症组（4．5±3．1）μV，t=4．27，P〈0．01]，非靶P2波幅降低正常组（4．2±1．2）μV，抑郁症组（2．3±1．3）μV，t=6．14，P〈0．01]。结论P300是评定抑郁症患者大脑综合功能的有效工具，在临床上值得进一步推广应用。

Experimental study of event-related potentials P300 of major depression

Objective： To study characteristic of event-related potentials P300（P300） in patients with major depression. Methods： With American Nicolet Bravo Instrument, P300 test was carried out in 35 patients with depressive disorder and 31 healthy adult controls（NC）. Results： Patients with major depression had significant delayed P3 latency NC （ 315 ± 29） ms, depressive disorder（341 ± 31 ） ms, t = 3.50, P 〈 0.01 ], delayed P2 latency NC （ 165 ± 19） ms, depressive disorder（ 175 ± 21 ） ms, t = 2.02, P 〈 0.05 ], decreased P3 NC （9.5 ± 6. 1 ） μV, depressive disorder（4.5 ± 3.1 ） μV, t = 4.27, P 〈 0.01 ], and decreased P2 NC （4.2 ± 1.2）μV, depressive disorder（2.3 ± 1.3）μV, t = 6.14, P 〈 0.01 ] amplitude of P300 than those of the controls at Oz. Conclusion： P300 is a useful immanent for assessing the brain malfunction of depressive disorder, and its clinical application is suggested. The characteristics of P300 of depressive disorder patients deserve further studying.