康莱特注射液联合肝动脉化学栓塞治疗中晚期原发性肝癌疗效观察

目的探讨康莱特注射液联合肝动脉化学栓塞(TACE)治疗中晚期原发性肝癌的疗效。方法将48例原发性肝癌(HCC)患者随机分为两组,治疗组(康莱特加TACE)24例;对照组(单纯TACE)24例。用放射免疫法检测血清甲胎蛋白(AFP)定量,检查肝脏B超、CT及肝肾功能,观察患者治疗前后临床主要症状的变化及不良反应。结果治疗组和对照组的显效、有效、无效、恶化分别为10、8、5、1和3、10、5、4例,治疗组总有效率(75.00%)明显优于对照组(54.17%,P<0.05)。两组治疗后AFP比治疗前均有显著下降(P<0.05),且治疗组带瘤生存时间(1.2年)优于对照组(P<0.05)。结论康莱特注射液联合TACE可有效治疗肿瘤,是治疗失去手术治疗机会的HCC的有效方法之一。

Effects of transcatheter arterial chemoenboliaztion combined with kanglaite injection on patients with advanced unresectable hepatocellular carcinoma

Objective To evaluate effects transcatheter arterial chemoembolization(TACE) combined with kanglaite injection on patients with advanced unresectable hepatocellular carcinoma.Methods Forty-eight patients suffered with hepatocellular carcinoma(HCC) were randomly distributed into two groups.In treatment group,24 patients received kanglaite injection after TACE,and 24 patients in the control group were treated with TACE simply.The serum a-fetal protein(AFP) was detected by raido-immunological technology.At the same time,the observed indexes including the changes of symptoms and signs,side effects,Ultra-sound,CT and liver or kidney kidney functions were considered.Results In the treatment group,ten cases were evaluated as 10CR,8PR,5NC,and 1PD,compared with the control group(CR,PR,NC and PD were,3,10,5 and 4 cases respectively).The effects response rate(CR PR) was 75% in the treatment group were superior to those in the control group 54.17%((P<)0.05).AFP in the treatment group decreased more significant than that in the control group(P<0.05).Conclusion The treatment for HCC combined Kanglaite injection with TACE could inactivate the tumor cells effectively.It is an effective method for HCC patients who have lost the surgical chance.