低分子量肝素钠治疗儿童原发性肾病综合征97例疗效分析

目的:探讨采用低分子量肝素钠对儿童原发性肾病综合征的治疗效果.方法:将我院2009年1月至2010年10月收治的97例儿童原发性肾病综合征患者随机分为两组.对照组患者给予常规治疗方法,治疗药物包括强的松、利尿剂、降脂药物、血管紧张素转换酶抑制剂等.实验组患者在对照组患者用药基础上,使用低分子量肝素钠治疗.比较两组患者的治疗效果,并对患儿尿蛋白、血纤维蛋白原、血白蛋白进行分析.将结果使用统计学处理.结果:实验组患者48例经过临床治疗后,患者完全缓解21例,部分缓解16例,总有效率为77.08%;对照组患者49例,完全缓解9例,部分缓解16例,总有效率为51.02%,实验组患者疗效明显优于对照组,经统计学分析,P<0.05.观察组患者的尿蛋白、血纤维蛋白下降,血清白蛋白上升,与对照组比较,差异显著,P<0.05.结论:在治疗儿童原发性肾病综合征时,为患者提供低分子量肝素,效果更好,值得在临床推广使用.

Clinical Analysis of Low Molecular Weight Heparin Sodiumon 97 Children with Primary Nephrotic Syndrome

Objective: To discuss the effect of low molecular weight heparin sodium on children with primary nephrotic syndrome.Method: Divided the 97 children with primary nephrotic syndrome who were treated in my hospital from Jan.2009 to Oct.2010 into two groups randomly.Patients in the control group received routine treatment,Therapeutic drugs includes prednisone,diuretics,lipid-lowering drugs,angiotensin-converting enzyme inhibitor and so on.On the medical basis of the control group,the patients in the experimental group used the low molecular weight heparin sodium.Compared the treatment effect of the two groups,and anlyzed the urinary protein,fibrinogen,albumin of the children.The results were processed using statistics.Result: After the clinical treatment,48 patients in the experimental group,21 patients remitted completely,16 patients remitted partly,the total efficiency was 77.08%;Among the 49 patients in the control group,9 patients remit completely,16 patients remit partly,the total efficiency was 51.02%,patients in the experimental group were better than the control group.According to the statistical analysis,P﹤0.05.The urinary protein and fibrinogen of the patients in the experimental group dropped,and the albumin rose.Compared with the control group,the difference was notable,P<0.05.Conclusion: In the treatment of the children with primary nephrotic syndrome,low molecular weight heparin has and better effect,which is worth promoting in clinical.