| 苦参碱对普萘洛尔所致豚鼠银屑病样皮损的实验研究 |
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| 引用本文： | 孙创斌,胡晋红,朱全刚,刘继勇,刘艳霞,沈奎亚. 苦参碱对普萘洛尔所致豚鼠银屑病样皮损的实验研究[J]. 解放军药学学报, 2009, 25(6): 476-478 |
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| 作者姓名： | 孙创斌 胡晋红 朱全刚 刘继勇 刘艳霞 沈奎亚 |
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| 作者单位： | 第二军医大学长海医院,药学部,上海,200433;第二军医大学长海医院,药学部,上海,200433;第二军医大学长海医院,药学部,上海,200433;第二军医大学长海医院,药学部,上海,200433;第二军医大学长海医院,药学部,上海,200433;第二军医大学长海医院,药学部,上海,200433 |
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| 摘 要： | 目的探讨苦参碱对豚鼠银屑病样皮损的治疗作用。方法给予豚鼠耳廓均匀涂抹5%普萘洛尔乳膏,2次/d,持续28d。从第21天起,再给予苦参碱药物。通过测量豚鼠耳廓厚度,HE染色、组织学评分以及ELISA法检测豚鼠血清IL-6、IL-8、IL-17等炎症细胞因子的变化等考察苦参碱的作用。结果苦参碱可降低豚鼠银屑病样皮损耳廓肿胀度,病理组织切片可见皮肤组织逐渐恢复正常,血清IL-6、IL-8、IL-17等炎症细胞因子水平也较模型组有明显降低。结论苦参碱对普萘洛尔所致豚鼠银屑病样皮损具有治疗作用。
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| 关 键 词： | 苦参碱 普萘洛尔乳膏 银屑病样皮损 |
Effects of Matrine on Guinea Pigs with Psoriasis-like Lesions Induced by Propranolol |
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| SUN Chuang-Bin,HU Jin-Hong,ZHU Quan-Gang,UU Ji-Yong,LIU Yan-Xia,SHEN Kui-Ya. Effects of Matrine on Guinea Pigs with Psoriasis-like Lesions Induced by Propranolol[J]. Pharmaceutical Journal of Chinese People's Liberation Army, 2009, 25(6): 476-478 |
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| Authors: | SUN Chuang-Bin HU Jin-Hong ZHU Quan-Gang UU Ji-Yong LIU Yan-Xia SHEN Kui-Ya |
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| Affiliation: | (Department of Pharmacy,Changhai Hospital,The Second Military Medical University,Shanghai 200433 China) |
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| Abstract: | Aim To explore the effect of matrine on guinea pigs with psoriasis-like lesions.Methods 5% propranolol cream was evenly applied on ears of guinea pigs,twice a day for 28d.From the 21st day guinea pigs were treated with matrine via oral administration.The thickness of guinea pig's ears was tested,and pathological skin changes were detected by HE staining.The level of IL-6,IL-8,IL-17 in serum was determined by ELISA assay.Results Matrine reduced the thickness of psoriasis-like lesions in guinea pigs,repaired ... |
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| Keywords: | matrine propranolol cream psoriasis-like lesions |
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