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| 藻酸双酸钠的降血糖作用 | |
| 引用本文： | 赵学增,王新铭,夏烨,张秋燕. 藻酸双酸钠的降血糖作用[J]. 中国药理学通报, 1993, 0(3) |
| 作者姓名： | 赵学增 王新铭 夏烨 张秋燕 |
| 作者单位： | 河北职工医学院药理教研室 保定071000(赵学增，王新铭，夏烨)，河北职工医学院药理教研室 保定071000(张秋燕) |
| 摘 要： | 家兔1次灌胃藻酸双酯钠(ISS)1.8mg·kg~(-1)、5.4mg·kg~(-1)及18mg·kg~(-1)可显著降低四氧嘧啶型糖尿病兔血糖.并可对抗由肾上腺素引起的高血糖.PSS1.8mg·kg~(-1).5.4mg·kg~(-1)对正常家兔血糖无影响.18mg·kg~(-1)可降低正常家兔血糖.糖耐量实验表明.大鼠5g·kg~(-1)葡萄糖灌胃.PSS5.4和18mg·kg~(-1)可对抗由粮负荷引起的血糖升高.PSS5.4和18mg·kg~(-1)连续灌胃5d可持续使四氧嘧啶型糖尿病大鼠血糖下降. |
| 关 键 词： | 藻酸双酯钠 甲苯磺丁脲 肾上腺素糖耐量 血糖 |
Effect of polysaccharide sulphate on reducing blood glucose |
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| ZHAO Xue-Zeng,WANG Xin-Ming,XIA Ye,ZHANG Qiu-Yian. Effect of polysaccharide sulphate on reducing blood glucose[J]. Chinese Pharmacological Bulletin, 1993, 0(3) | |
| Authors: | ZHAO Xue-Zeng WANG Xin-Ming XIA Ye ZHANG Qiu-Yian |
| Abstract: | Polysaccharide sulphate (PSS) 1. 8, 5. 4 and 18mg · kg-1 ig could remarkably reduce blood glucose of alloxan - induced diabetes in rabbits . The doses of PSS could decrease the high blood glucose caused by adrenaline . PSS 1. 8 and 5. 4mg · kg-1 could not reduce blood glucose concentration in normal rabbits, but PSS 18mg · kg-1 could do. The glucose to lerance test showed that PSS 5. 4 and 18mg ·kg-1 could reduce the increase of blood glucose level caused by glucose loading after administration of glucose in rats (5g · kg-1, ig) and could also persistently decrease blood glucose of alloxan - induced diabetes in rats after the doses of PSS ig for 5d. |
| Keywords: | polysaccharide sulphate Tolbutamide adrenaline glucose tolerance blood glucose |
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