Hematoporphyrin-mediated fluorescence reflectance imaging: application to early tumor detection in vivo in small animals |
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Authors: | Maddalena Autiero Rosanna Cozzolino Paolo Laccetti Marcello Marotta Maria Quarto Patrizia Riccio Giuseppe Roberti |
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Institution: | Dipartimento di Scienze Fisiche, Università di Napoli Federico II, Via Cinthia, 80126, Naples, Italy. |
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Abstract: | The in vivo early detection of subcutaneous human tumors implanted in small animals was studied by laser-induced fluorescence
reflectance imaging (FRI), with a hematoporphyrin (HP) compound as an exogenous optical contrast agent. Tumor detection was
shown to be possible just 3 days after the inoculation of tumor cells, when tumors were neither visible nor palpable. However,
this detection capability is limited to a temporal window of approximately 100 h from HP administration and to a low optical
contrast of the tumor (<2). |
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Keywords: | Hematoporphyrins Tumor Fluorescence Lasers Early diagnosis |
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