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| 山茶种子总皂苷碱水解产物的化学成分 | |
| 引用本文： | 李宁,李铣,冯志国,吉川雅之.山茶种子总皂苷碱水解产物的化学成分[J].中国药物化学杂志,2007,17(5):306-309. |
| 作者姓名： | 李宁 李铣 冯志国 吉川雅之 |
| 作者单位： | 1. 沈阳药科大学,中药学院,辽宁,沈阳,110016 2. 天津田边制药有限公司,天津,300385 3. 日本京都药科大学,生药学研究室,日本,京都,607-8494 |
| 摘 要： | 目的研究山茶Camellia sinensis(L) O.Kuntze]种子总皂苷碱水解产物的化学成分。方法采用反复制备型反相HPLC法分离纯化,通过理化常数测定和波谱分析鉴定其化学结构。结果从山茶种子总皂苷的碱水解产物中分离得到5个去酰基茶皂苷类化合物,即desacyl-assamsaponin A(1)、desacyl-assamsaponin D(2)、desacyl-assamsaponin E(3)、desacyl-assamsaponin F(4)、desacyl-theasaponin E(5)。结论对山茶种子总皂苷碱水解产物化学成分系统研究尚属首次,可为山茶皂苷类化合物生物活性的构效关系研究提供参考。 |
| 关 键 词： | 山茶种子 总皂苷 碱水解 化学成分 |
| 文章编号： | 1005-0108（2007）05-0306-04 |
| 收稿时间： | 2007-03-06 |
| 修稿时间： | 2007年3月6日 |
Chemical constituents of alkaline hydrolysis product of tea seed saponin from Camellia sinensis |
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| LI Ning,LI Xian,FENG Zhi-guo,YOSHIKAWA Masayuki.Chemical constituents of alkaline hydrolysis product of tea seed saponin from Camellia sinensis[J].Chinese Journal of Medicinal Chemistry,2007,17(5):306-309. | |
| Authors: | LI Ning LI Xian FENG Zhi-guo YOSHIKAWA Masayuki |
| Institution: | 1. School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China ; 2. Tianjin Tanabe Seiyaku Co. Ltd., Tianjin 300385, China ; 3. Kyoto Pharmaceutical University, Kyoto 607- 8494, Japan |
| Abstract: | Aim To study the chemical constituents in alkaline hydrolysis product of tea seed saponin from Camellia sinensis(L.)O.Kuntze.Methods The compounds were isolated by repeated RP-HPLC on ODS column and identified on the basis of physico-chemical constants and spectral analysis.Results Five compounds were isolated and their structures were identified as desacyl-assamsaponin A(1),desacyl-assamsaponin D(2),desacyl-assamsaponin E(3),desacyl-assamsaponin F(4),desacyl-theasaponin E(5).Conclusion It was the first time to study the chemical composition of the alkaline hydrolysis products of tea seed saponins from Camellia sinensis(L.)O.Kuntze.The research results provided the chemiacal foundation for the structure-function relationship study of tea seed saponins. |
| Keywords: | tea seed saponin alkaline hydrolysis chemical consitutents |
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