Growth hormone secretagogues: recent advances and applications |
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| Affiliation: | 1. Division of Nutritional Sciences, University of Illinois at Urbana-Champaign, IL;2. Department of Food Science and Human Nutrition, University of Illinois at Urbana-Champaign, IL;3. Department of Chemistry, University of Illinois at Urbana-Champaign, IL;4. The Beckman Institute, University of Illinois at Urbana-Champaign, IL;5. Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR;6. Abbott Nutrition, Columbus, OH;1. Department of Medicine, University of British Columbia, Vancouver, Canada;2. Department of Biochemistry and Molecular Biology, Faculty of Science and Technology, University of the Basque Country, P.O. Box 644, 48080 Bilbao, Spain;3. Memorial Sloan Kettering Cancer Center, New York, NY, United States |
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| Abstract: | ![]()
The discovery of a new class of compounds that stimulate the release of growth hormone (GH) in a manner distinctly different from growth hormone-releasing hormone (GHRH) is advancing the understanding of the mechanisms that control GH secretion. These compounds, the GH secretagogues, act at both pituitary and hypothalamic levels, and might even elicit effects in the CNS and peripheral systems. A receptor with high affinity for the GH secretagogues has been identified and several observations suggest the presence of additional receptors. The existence of these specific endogenous receptors could indicate that the mechanism of GH release is not yet fully understood. Several potential indications have been explored clinically and, as some of these compounds are orally active, they could offer attractive alternatives to recombinant human growth hormone (hGH) in treating GH disorders such as growth hormone deficiency (GHD), age-related conditions, obesity and catabolic conditions. |
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