冠状动脉狭窄程度与冠心病危险因素的关系

为探讨不同冠状动脉造影病变程度与冠心病危险因素之间的关系,对1997～2001年间行选择性冠状动脉造影的649例住院患者进行冠心病危险因素分析.结果发现危险因素中高血压病史、糖尿病史、吸烟史、男性及高LDL组中冠状动脉狭窄的百分率均明显高于无危险因素组(P=0.000 1～0.016);冠状动脉造影病变组中年龄高低、高血压病程、糖尿病程、吸烟量、血Glu、SBP、TC、LDL和ApoA1的均值明显高于冠状动脉造影正常组(t=2.423～7.816,P=0.000 1～0.016);高龄、高血压病程、糖尿病程、吸烟量、血Glu、TC与病变冠脉积分、冠脉病变积分及病变支数呈显著正相关性(r=0.093～0.29,P=0.000 1～0.022).Logistic 回归分析显示,高龄(P=0.000 1)、高血压病程(P=0.007)、吸烟量(P=0.000 1)、高LDL(P=0.003)为冠心病的独立危险因素.

Relationship between risk factors of coronary artery disease and severity of coronary artery stenosis

This study is to investigate the relationship between the risk factors of coronary artery disease and the severity of the coronary artery stenosis. A total of 649 consecutive patients(1997 2001) were studied retrospectively. All patients suspected of coronary artery disease underwent a selective coronary angiography and received a survey of risk factors during the hospitalization. Binary Logistic regression analysis showed that male sex, smoking, hyperlipidemia (low density lipoprotein, LDL) and course of hypertension were independent risk factors for coronary artery disease ( P =0.000 1 0.016).Significant correlations between the severity of the coronary artery stenosis and aging, the amount of cigarettes, level of plasma LDL, level of plasma Glu, course of diabetes mellitus,and the course of hypertension were found through the Bivariate Correlation analysis( r =0.093 0.29, P =0.000 1 0.022). It is suggested that not only the development but also the severity of the coronary artery stenosis are affected by the risk factors of aging, smoking, hyperlipidemia (LDL), and hypertension.