阿魏酸钠联合羟氯喹治疗老年类风湿关节炎的临床观察

目的探讨阿魏酸钠（SF）治疗老年类风湿关节炎（EORA）的疗效和安全性。方法将52例EORA患者随机分为羟氯喹（HCQ）治疗组（对照组，24例，口服塞来昔布200mg／次，2次／d；HCQ200mg／d），阿魏酸钠（SF）联合HCQ治疗组（治疗组，28例，在对照组治疗基础上加用SF300mg入0．9％氯化钠溶液250ml静滴，1次／d），两组均4周为一疗程。于治疗前后分别测定关节疼痛指数、关节肿胀指数、晨僵时间、双手平均握力、20m步行时间、红细胞沉降率（ESR）、C-反应蛋白（CRP）、类风湿因子（RF）、免疫球蛋白（Ig）、血尿常规、血清丙氨酸氨基转移酶（ALT）、血清天门冬氨酸氨基转移酶（AST）、血清碱性磷酸酶（ALP）、血清肌酐（Cr）、血清尿素氮（BUN）、血清尿酸（UA）等指标，治疗前后检查心电图、眼科情况，记录不良反应。结果两组患者疗效间差别有显著性意义（P〈0．05），治疗组患者治疗后关节疼痛指数、关节肿胀指数、晨僵时间、双手平均握力、20m步行时间、ESR、CRP、RF、Ig等指标与对照组间差别均有显著性意义（P〈0．05）。两组不良反应发生率间差别无显著性意义（P〉0．05）。结论SF联合HCQ治疗EORA疗效较好。

Clinical Treatment of Elderly Rheumatoid Arthritis with Sodium Ferulate and Hydroxychloroquine

Objective To study the therapeutic efficacy and safety of Sodium Ferulate (SF) in treating elderly onset rheumatoid arthritis (EORA).Methods Totally 52 EORA cases were randomly divided into 2 groups: the control group treated with celecoxib 200mg,two times a day,and Hydroxychloroquine (HCQ) 200mg/d;and the trial group treated with intravenous dripping of SF 300mg/d in 250 ml of 0.9% saline additionally besides the therapy for the control group,the therapeutic course for both groups was 4 weeks.Before and after treatment,the indexes of joint tenderness,swelling and morning stiffness;the average power of gripping of both hands,the time for 20 m walking,erythrocyte sedimentation rate (ESR),C-reactive (CRP),rheumatoid factor (RF),immunoglobulin (Ig),routine blood and urine examinations,alanine amiotransferase (ALT),aspartate aminotransferase (AST),serum alkaline phosphatase (ALP),serum creatinine (SCr),blood urea nitrogen (BUN),and uric acid (UA) were detected;and the electrocardiogram (EKG),ophthalmic conditions and untoward effects were recorded too.Results There was a significant difference in effects between the two groups (P<0.05).After treatment,there were significant differences in the indexes of joint tenderness,swelling and morning stiffness;the average power of gripping of both hands,the time for 20 m walking,ESR,CRP,RF and Ig(P<0.05).And there was no significant difference in untoward effects between the two groups (P>0.05).Conclusion The therapy of SF and HCQ is of better effect in treating EORA.