生活方式干预改善超重及肥胖青少年氧化应激状态

目的超重和肥胖已成为影响青少年健康的关键问题。本研究探讨饮食及运动干预对青少年体内氧化应激状态的影响。方法124名受试者中的93名超重及肥胖青少年年龄（13．6±0．7）岁，体重指数（BMI22．4～34．1kg／m。）随机分为四组：饮食干预组（D）、运动干预组（E）、饮食运动干预组（DE）、超重及肥胖对照组（O）。饮食方案根据研究对象的年龄及理想体重制定；运动干预为放学后1h中等强度运动，每周4次。干预周期为10周，干预前后分别进行人体测量、身体成分、代谢及氧化应激等指标检测。31名正常体重者为对照组。结果超重及肥胖组的空腹血糖、TC、LDL—C和MDA水平明显高于正常体重组（P〈0．05），SOD水平低于正常体重组（P〈0．05）；MDA水平与体重、BMI、TC、LDL-C呈正相关（R=0．209，0．228，0．274，0．263，P〈0．05），SOD与体重及BMI呈负相关（R=一0．334，一0．362，P〈0．05）；干预后D、E、DE组BMI、腰围、全身脂肪显著下降（P〈0．05），D和E组的MDA水平下降（P〈0．05）；两个运动干预组的TC和LDL—C下降亦达统计学差异（P〈0．05）。结论超重青少年在糖脂代谢正常阶段体内即存在氧化应激失衡状态。为期10周的饮食和（或）运动的生活方式干预在改善青少年超重状态、调节血脂水平的同时，还可显著降低其体内的氧化应激水平。

Lifestyle intervention improves oxidant stress in overweight or obese adolescents

Objective To explore the effects of diet and/or exercise intervention on oxidative stress of overweight or obese adolescents. Methods Thirty-one adolescents with normal body weight （normal control group） and 93 overweight or obese adolescents （ average age （ 13.6 ± 0. 7） years ; body mass index （BMI） 22. 4 to 34. 1 kg/m2 ） were enrolled in this study. The overweight or obese participants were then randomly assigned to the diet group （group A）, exercise group （group B）, diet plus exercise group （group C） , and non-intervention group （ group D ）. Individualized caloric intake was carried out. One-hour after- school exercise was performed once per day, 4 days per week for 10 weeks. Changes of anthropometry, body composition, and metabolic biomarkers were determined. Results Compared to the normal control group, serum levels of fasting glucose, total cholesterol （ TC）, low-density lipoprotein cholesterol （ LDL-C ）, and malondialdehyde （MDA） of the in overweight group were significant increased （ all P 〈 0. 05 ） , although the level of SOD was significant decreased （ P 〈 0. 05 ） . Serum MDA level was positively correlated with bodyweight, BMI, TC, and LDL-C （ I~ values were {}. 2{Y：）, {）. 22~, 0. 234, and O. 263, respectively ; all P 〈 0. 05 ）, and serum SOD level was negatively correlated with bodyweight and BMI （R values were - O. 334 and - 0. 362, respectively ; both P 〈 0. 05 ）. Group A, B and C showed a significant decrease in BMI, waist circumference and body fat after the intervention （all P 〈 0. 05 ）. The level of MDA was significantly decreased after the intervention in group A and B （ both P 〈 0. 05 ） ; the levels of TC and LDL-C were significantly decreased in group B and C （ both P 〈 0. 05 ）. Conclusion ： Oxidative stress could have existed in overweight adolescents even when their serum glucose and lipid profiles are at a normal level. Ten-week diet and/or exercise intervention may contribute to improved body weight control, lipid metabolism, and oxidative stress response in this population.