| 帕利哌酮与利培酮治疗精神分裂症的对照研究 |
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| 引用本文： | 罗汝琴,陈仁云. 帕利哌酮与利培酮治疗精神分裂症的对照研究[J]. 中国民康医学, 2011, 23(23): 2913-2914,2940. DOI: 10.3969/j.issn.1672-0369.2011.23.020 |
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| 作者姓名： | 罗汝琴 陈仁云 |
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| 作者单位： | 1. 武汉市武昌医院精神科,湖北武汉,430063
2. 武汉市优抚医院 |
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| 摘 要： | 目的:探讨帕利哌酮缓释片治疗精神分裂症的疗效和安全性。方法:将158例精神分裂症患者随机分成帕利哌酮组(80例)和利培酮组(78例),分别给予帕利哌酮缓释片和利培酮口服治疗8周,在治疗前及治疗第2、4、8周末采用阳性与阴性症状量表(Positive andNegative Syndrome Scale,PANSS)和不良反应症状量表(Treatment Emergent Symptoms Scale,TESS)评定疗效和不良反应。结果:后两组患者PANSS量表总分及各因子分较治疗前均有明显下降,差异有统计学意义(P<0.05或P<0.01);在治疗的第2周末,帕利哌酮组PANSS总评分明显低于利培酮组,其差异有统计学意义(P<0.01),其余各组间无明显差异(P>0.05);帕利哌酮的不良反应少且轻。结论:帕利哌酮缓释片起效快,是治疗精神分裂症安全、有效的药物。
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| 关 键 词： | 帕利哌酮缓释片 利培酮 精神分裂症 |
A Control Study between Paliperidone Extended- release Tablets and Risperidone in the Treatment of Schizophrenia |
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| LUO Ru-qin,CHEN Ren-yun. A Control Study between Paliperidone Extended- release Tablets and Risperidone in the Treatment of Schizophrenia[J]. medical journal of chinese peoples health, 2011, 23(23): 2913-2914,2940. DOI: 10.3969/j.issn.1672-0369.2011.23.020 |
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| Authors: | LUO Ru-qin CHEN Ren-yun |
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| Affiliation: | LUO Ru-qin,CHEN Ren-yun(Wuchang Hospital,Wuhan 430063,China) |
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| Abstract: | Objective:To explore the clinical efficacy and safety of paliperidone extended-release tablets(paliperidone ER)treatment on schizophrenia.Methods:158 schizophrenics were randomly divided into paliperidone ER treatment group(80) and risperidone group(78) for 8 weeks.The efficacy and side effects were assessed with PANSS and TESS before treatment and after 2,4,8 weeks.Results: After treatment,there were significant differences in scores of total PANSS,positive factor,negative factor,and general factor(P<0.05 ... |
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| Keywords: | Paliperidone ER Risperidone Schizophrenia |
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