microRNA：胰腺癌早期诊断的潜在标记物

胰腺癌以其与发病率近乎持平的病死率，已成为最致命的恶性肿瘤之一，如何提高胰腺癌的早期诊断率和胰腺癌的治疗及预后效果是目前亟待解决的问题。microRNA（miRNA）在胰腺癌早期就出现异常表达，并可能成为肿瘤标志物用于胰腺癌的早期诊断。笔者通过回顾胰腺癌早期诊断的进展及目前存在的问题，重点探讨miRNA在胰腺癌早期诊断中的潜在重要作用。

MicroRNAs: potential markers for early diagnosis of pancreatic cancer

Pancreatic cancer is one of the most lethal cancers because of its nearly identical mortality and morbidity rates, and how to improve the early detection rate, treatment and prognosis of this disease is presently an urgent issue. Aberrant expression of microRNAs (miRNAs) have been found in pancreatic cancer at its early stage, so miRNAs may be used as tumor markers for early detection of pancreatic cancer. In this paper, the authors, after reviewing the advances and current problems in early diagnosis of pancreatic cancer, address the potentially important role of miRNAs in early diagnosis of pancreatic cancer.