锌对小鼠肝金属硫蛋白合成的影响

本文研究了小鼠在宽的剂量范用内（１０，２０，４０，８０，１００，１２０，１４０，１６０，１８０，２００ｍｇ／ｋｇｂｗ）口服锌（Ｚｎ）盐时，对肝金属硫蛋白（ＭＴ）合成的影响。结果显示：因服用过量Ｚｎ（２＋），按剂量──效应关系发生肝ＭＴ的诱导合成，而且在肝Ｚｎ浓度和肝ＭＴ浓度之间存在正向关系。表明Ｚｎ是一个ＭＴ的诱导剂。在口服Ｚｎ８０～１００ｍｇ／ｋｇ的剂量范围时，无论是肝ＭＴ水平或肝Ｚｎ水平均有明显的改变。提示：在Ｚｎ诱导ＭＴ合成中，存在一个敏感的剂量范围。

INFLUENCE OF ZINC IN THE SYNTHESIS OF HEPATIC METALLOTHIONEIN IN MICE

he influence of oral zinc salts at a wide range of doses(10,20,40,60,80,100,120,140,160,180,200 mg/kg)with regard to the svnthesis of metal-lothionein(MT)in mice liver was investigated.The results showed the in,duced synthesis of hepatic MT occurs in a dose-dependent manner in respon-se to the administration of excess Zn(2+)。A positive correlation was notedbetween the concentrations of hepatic Zn and hepatic MT。It also showedthat Zn was an inducer of MT,Wlien mice received an orallv administrati-on of Zn at the dosage of 80-100 mg/kg,there were significant changes eit-her in hepatic MT or in hepatic Zn levels。